Detalhes bibliográficos
| Resumo: | Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis. |
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| Autores principais: | Carvalho, Agostinho |
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| Outros Autores: | Pasqualotto, A. C.; Pitzurra, L.; Romani, L; Denning, D. W.; Rodrigues, Fernando José dos Santos |
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| Assunto: | Aged Aspergillosis Aspergillosis, Allergic Bronchopulmonary Aspergillus fumigatus Case-Control Studies Cohort Studies Female Humans Lung Diseases, Fungal Male Middle Aged Polymorphism, Single Nucleotide Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptor 9 |
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| Ano: | 2008 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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