Detalhes bibliográficos
| Resumo: | Institutionalization adversely impacts children's emotional functioning, proving related to attachment disorders, perhaps most notably that involving indiscriminate behavior, the subject of this report. In seeking to extend work in this area, this research on gene X environment (GXE) interplay investigated whether the serotonin transporter (5-HTTLPR) and val66met Brain-Derived Neurotrophic Factor (BDNF) polymorphisms moderated the effect of institutional care on indiscriminate behavior in preschoolers. Eighty-five institutionalized and 135 home-reared Portuguese children were assessed using Disturbances of Attachment Interview (DAI). GXE results indicated that s/s homozygotes of the 5-HTTLPR gene displayed significantly higher levels of indiscriminate behavior than all other children if institutionalized, something not true of such children when family reared. These findings proved consistent with the diathesis-stress rather than differential-susceptibility model of person×environment interaction. BDNF proved unrelated to indiscriminate behavior. Results are discussed in relation to previous work on this subject of indiscriminate behavior, institutionalization and GXE interaction. |
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| Autores principais: | Mesquita, Ana Raquel Marcelino |
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| Outros Autores: | Belsky, J.; Li, Z.; Baptista, J.; Carvalho-Correia, Eduarda; Maciel, P.; Soares, Isabel |
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| Assunto: | Brain-Derived Neurotrophic Factor Child Child, Institutionalized Child, Preschool Family Gene-Environment Interaction Genetic Predisposition to Disease Genotype Interview, Psychological Models, Genetic Serotonin Plasma Membrane Transport Proteins Polymorphism, Genetic Social Behavior Institutionalization Indiscriminate behavior BDNF 5-HTTLPR Diathesis-stress Differential susceptibility |
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| Ano: | 2015 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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