Publicação

Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer

Detalhes bibliográficos
Resumo:	MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer.
Autores principais:	Marques, Marcia M.
Outros Autores:	Evangelista, Adriane F.; Macedo, Taciane; Vieira, René Aloisio da Costa; Scapulatempo-Neto, Cristovam; Reis, R. M.; Carvalho, André L.; Silva, Ismael Dale Cotrim Guerreiro da
Assunto:	Adult Aged Analysis of Variance Biomarkers, Tumor Breast Neoplasms Carcinogenesis Case-Control Studies Down-Regulation Female Gene Expression Regulation, Neoplastic Humans Logistic Models MicroRNAs Middle Aged Neoplasm Invasiveness Neoplasm Staging Prospective Studies Real-Time Polymerase Chain Reaction Reference Values Risk Factors Sensitivity and Specificity Breast Cancer Biomarkers Tumor Suppressors Early Detection
Ano:	2018
País:	Portugal
Tipo de documento:	artigo
Tipo de acesso:	acesso aberto
Instituição associada:	Universidade do Minho
Idioma:	inglês
Origem:	RepositóriUM - Universidade do Minho

Descrição
Resumo:	MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer.