Publicação
The Role of Biliverdin Reductase A in Malaria
| Resumo: | "Malaria, a life-threatening disease caused by Plasmodium spp., remains a major global health burden. While considerable progress has been made in characterizing host resistance mechanisms that reduce parasite burden during Plasmodium infection, our understanding of these pathways remains incomplete. Disease tolerance mechanisms that mitigate tissue damage during infection without directly affecting parasite burden are even less well-understood. This PhD thesis explores the hypothesis that biliverdin reductase A (BVRA) and its end product, unconjugated bilirubin, confer host protection against malaria through both resistance and disease tolerance mechanisms.(...)" |
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| Autores principais: | Figueiredo, Ana |
| Assunto: | infection Plasmodium Malaria biliverdin reductase A (BVRA) resistance BVRA/bilirubin axis |
| Ano: | 2026 |
| País: | Portugal |
| Tipo de documento: | tese de doutoramento |
| Tipo de acesso: | acesso embargado |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | "Malaria, a life-threatening disease caused by Plasmodium spp., remains a major global health burden. While considerable progress has been made in characterizing host resistance mechanisms that reduce parasite burden during Plasmodium infection, our understanding of these pathways remains incomplete. Disease tolerance mechanisms that mitigate tissue damage during infection without directly affecting parasite burden are even less well-understood. This PhD thesis explores the hypothesis that biliverdin reductase A (BVRA) and its end product, unconjugated bilirubin, confer host protection against malaria through both resistance and disease tolerance mechanisms.(...)" |
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