Publicação
Electro-responsive on-demand drug delivery system for e-Patches
| Resumo: | Controlled drug delivery technologies represent a significant advancement in modern phar- macotherapy, offering distinct advantages over traditional drug delivery systems. Unlike tradi- tional methods, where drugs are often absorbed by various parts of the body before reaching the intended treatment location, resulting in the need for higher drug concentrations and po- tentially causing adverse effects, controlled-release systems emerge to overcome these limita- tions. Therefore, to address these shortcomings, this study explores a drug delivery system with conductive polymers for electrical stimulus responsiveness, by employing non-invasive, exter- nally controlled drug release mechanisms, for topical applications. Incorporating electrical stimulation ensures a more timely and effective response to treatment - this type of stimulation allows for dynamic control over drug release kinetics, by modulating the electrical signals and enabling tailored dosing regimens based on individual patient needs, while minimizing sys- temic exposure. Electrospun cellulose acetate fibers impregnated with a cationic drug were functionalized with polypyrrole and poly(3,4-ethylenedioxythiophene) to enable electrical stimulation. Results revealed that negative potentials enhanced the release of this positively charged drug molecule through the fibers, while positive potentials had the opposite effect. Consequently, the conducted study demonstrates the influence of electrical stimulus type and the charge of the selected model drug on release profiles and allows to contribute to the de- velopment of more personalized and efficient therapies in long-term dermatologic diseases, ultimately improving patient outcomes and enhancing their quality of life. |
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| Autores principais: | Marques, Marta Isabel Ramos |
| Assunto: | Controlled drug delivery systems electrospinning cellulose acetate conductive polymers polypyrrole PEDOT |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | Controlled drug delivery technologies represent a significant advancement in modern phar- macotherapy, offering distinct advantages over traditional drug delivery systems. Unlike tradi- tional methods, where drugs are often absorbed by various parts of the body before reaching the intended treatment location, resulting in the need for higher drug concentrations and po- tentially causing adverse effects, controlled-release systems emerge to overcome these limita- tions. Therefore, to address these shortcomings, this study explores a drug delivery system with conductive polymers for electrical stimulus responsiveness, by employing non-invasive, exter- nally controlled drug release mechanisms, for topical applications. Incorporating electrical stimulation ensures a more timely and effective response to treatment - this type of stimulation allows for dynamic control over drug release kinetics, by modulating the electrical signals and enabling tailored dosing regimens based on individual patient needs, while minimizing sys- temic exposure. Electrospun cellulose acetate fibers impregnated with a cationic drug were functionalized with polypyrrole and poly(3,4-ethylenedioxythiophene) to enable electrical stimulation. Results revealed that negative potentials enhanced the release of this positively charged drug molecule through the fibers, while positive potentials had the opposite effect. Consequently, the conducted study demonstrates the influence of electrical stimulus type and the charge of the selected model drug on release profiles and allows to contribute to the de- velopment of more personalized and efficient therapies in long-term dermatologic diseases, ultimately improving patient outcomes and enhancing their quality of life. |
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