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A computational method for the identification of dengue, zika and chikungunya virus species and genotypes

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Detalhes bibliográficos
Resumo:In recent years, an increasing number of outbreaks of Dengue, Chikungunya and Zika viruses have been reported in Asia and the Americas. Monitoring virus genotype diversity is crucial to understand the emergence and spread of outbreaks, both aspects that are vital to develop effective prevention and treatment strategies. Hence, we developed an efficient method to classify virus sequences with respect to their species and sub-species (i.e. serotype and/or genotype). This tool provides an easy-to-use software implementation of this new method and was validated on a large dataset assessing the classification performance with respect to whole-genome sequences and partial-genome sequences.
Autores principais:Fonseca, Vagner S.
Outros Autores:Libin, Pieter J. K.; Theys, Kristof; Faria, Nuno Rodrigues; Nunes, Márcio Roberto Texeira; Restovic, Maria I.; Freire, Murilo; Giovanetti, Marta; Cuypers, Lize; Nowé, Ann; Abecasis, AB; Deforche, Koen; Santiago, Gilberto A.; de Siqueira, Isadora Cristina; San, Emmanuel J.; Machado, Kaliane C.B.; Azevedo, Vasco Ariston De Carvalho; de Filippis, Ana Maria Bispo; da Cunha, Rivaldo Venâncio; Pybus, Oliver George; Vandamme, AM; Alcantara, L. C. J.; de Oliveira, Túlio
Assunto:Computer Science Applications Virology Infectious Diseases Genetics SDG 3 - Good Health and Well-being
Ano:2019
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL
Descrição
Resumo:In recent years, an increasing number of outbreaks of Dengue, Chikungunya and Zika viruses have been reported in Asia and the Americas. Monitoring virus genotype diversity is crucial to understand the emergence and spread of outbreaks, both aspects that are vital to develop effective prevention and treatment strategies. Hence, we developed an efficient method to classify virus sequences with respect to their species and sub-species (i.e. serotype and/or genotype). This tool provides an easy-to-use software implementation of this new method and was validated on a large dataset assessing the classification performance with respect to whole-genome sequences and partial-genome sequences.