Publicação
Establishment of bioengineered glucose-responsive nanoparticles for type 2 diabetes mellitus therapy
| Resumo: | "Type 2 diabetes mellitus (T2DM) is one of the biggest health problems in the world. Glucagon like peptide-1, an endogenous gastrointestinal incretin hormone that stimulates insulin secretion, is considered an attractive therapeutic agent for T2DM treatment. Nevertheless, its short half-life has led to the development of longer half-life GLP-1 analogues, as exenatide. Still, current dosage forms for exenatide delivery are not exempt of shortcomings. Nanotechnology-based systems may offer several advantages over conventional dosage forms for drug delivery.(...)" |
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| Autores principais: | Fonseca, Filipa Ribeiro da |
| Assunto: | Closed-loop delivery system Glucagon like peptide-1 analogues glucose-oxidase pH-sensitive nanoparticles |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | "Type 2 diabetes mellitus (T2DM) is one of the biggest health problems in the world. Glucagon like peptide-1, an endogenous gastrointestinal incretin hormone that stimulates insulin secretion, is considered an attractive therapeutic agent for T2DM treatment. Nevertheless, its short half-life has led to the development of longer half-life GLP-1 analogues, as exenatide. Still, current dosage forms for exenatide delivery are not exempt of shortcomings. Nanotechnology-based systems may offer several advantages over conventional dosage forms for drug delivery.(...)" |
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