Publicação
Determining the role of Sympathetic Nervous System Activity in the control of Body Weight and Metabolism
| Resumo: | "Some humans resist fat gain with overeating, whereas others easily store excess weight (Riveros-McKay et al., 2019). The possibility that differences in the thermogenesis could underlie the susceptibility to obesity was first proposed over a century ago (Neumann, 1902), a phenomenon controlled by the elevation of sympathetic-nervous-system (SNS) activity (Schwartz et al., 1983). We first developed a model of loss-of-function of the SNS, where we performed genetic sympathectomy in mice, making them highly prone to obesity despite having the same energy intake as the non-sympathectomized controls (Pereira et al., 2017).(...)" |
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| Autores principais: | Mahú, Inês |
| Assunto: | Body-Weight Nervous System Metabolism |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | tese de doutoramento |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | "Some humans resist fat gain with overeating, whereas others easily store excess weight (Riveros-McKay et al., 2019). The possibility that differences in the thermogenesis could underlie the susceptibility to obesity was first proposed over a century ago (Neumann, 1902), a phenomenon controlled by the elevation of sympathetic-nervous-system (SNS) activity (Schwartz et al., 1983). We first developed a model of loss-of-function of the SNS, where we performed genetic sympathectomy in mice, making them highly prone to obesity despite having the same energy intake as the non-sympathectomized controls (Pereira et al., 2017).(...)" |
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