Publicação
Exploring Thermomyces lanuginosus Lipase (TLL)-PdNPs Nanohybrid as Suitable Catalyst for One-pot Synthesis of Bis(3-indolyl)phenylmethane
| Resumo: | Palladium nanohybrids were synthesized and applied to the one-pot synthesis of bis(3-indolyl)methanes by selective C−C bond reaction from benzyl alcohol and indole. A T. lanuginosus lipase-palladium nanoparticles hybrid (Pd@TLL) was synthesized, yielding PdNPs with an average diameter size of 5 nm. This heterogeneous catalyst was first tested in the selective oxidation of benzyl alcohol to benzaldehyde in different solvents. Then, the direct formation of bis(3-indolyl)methane, by in situ oxidation and C−C coupling, was successfully evaluated under different conditions, obtaining >99 % conversion at 80 °C in toluene, with a TOF value of 9 min−1 and 89 % in pure water, demonstrating the versatility of these biohybrids. |
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| Autores principais: | Santos, A. Sofia |
| Outros Autores: | Losada-Garcia, Noelia; Garcia-Sanz, Carla; Silva, Artur M. S.; Marques, M. Manuel B.; Palomo, Jose M. |
| Assunto: | bis(3-indolyl)methanes C−C bond formation indole nanohybrid palladium nanoparticles Catalysis Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | Palladium nanohybrids were synthesized and applied to the one-pot synthesis of bis(3-indolyl)methanes by selective C−C bond reaction from benzyl alcohol and indole. A T. lanuginosus lipase-palladium nanoparticles hybrid (Pd@TLL) was synthesized, yielding PdNPs with an average diameter size of 5 nm. This heterogeneous catalyst was first tested in the selective oxidation of benzyl alcohol to benzaldehyde in different solvents. Then, the direct formation of bis(3-indolyl)methane, by in situ oxidation and C−C coupling, was successfully evaluated under different conditions, obtaining >99 % conversion at 80 °C in toluene, with a TOF value of 9 min−1 and 89 % in pure water, demonstrating the versatility of these biohybrids. |
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