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Organismal homeostasis in sepsis

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Detalhes bibliográficos
Resumo:"Optimal organismal function and survival in adverse conditions require robust homeostatic responses to challenging environmental conditions. Surviving a severe infection requires the synergy between resistance and disease tolerance, two evolutionarily conserved defense strategies that limit disease severity. Sepsis – a dysregulated host response to infection that leads to high risk of death – is a prime example of extreme homeostasis disruption and therefore constitutes an excellent model to study homeostasis and inter-organ communication principles.(...)"
Autores principais:Colaço, Henrique Guerra Gonçalves
Assunto:infection homeostasis sepsis antibiotics
Ano:2020
País:Portugal
Tipo de documento:tese de doutoramento
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL
Descrição
Resumo:"Optimal organismal function and survival in adverse conditions require robust homeostatic responses to challenging environmental conditions. Surviving a severe infection requires the synergy between resistance and disease tolerance, two evolutionarily conserved defense strategies that limit disease severity. Sepsis – a dysregulated host response to infection that leads to high risk of death – is a prime example of extreme homeostasis disruption and therefore constitutes an excellent model to study homeostasis and inter-organ communication principles.(...)"