Publication
Is the association between Immunoglobulin A Nephropathy and Spondyloarthritis real?
| Summary: | Spondyloarthritis is a group of inflammatory rheumatic diseases characterized by inflammation of the spine and sacroiliac joints. Extra-musculoskeletal manifestations may also occur, although kidney involvement is rarely reported. Immunoglobulin A nephropathy is one of the most common types of glomerulonephritis, and it can be primary or associated with various diseases, such as spondyloarthritis. Several cases have been reported, mostly through case reports and small case series, pointing to a possible common pathophysiology between these two diseases. However, there is scarce information on the prevalence of renal involvement, particularly Immunoglobulin A nephropathy, among Spondyloarthritis Portuguese patients. We present 5 cases of Immunoglobulin A nephropathy in patients with Spondyloarthritis, resulting from a multicentre Portuguese collaboration, accompanied by a systematic literature review to understand this possible association. |
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| Main Authors: | Silva, S. P. |
| Other Authors: | Rodrigues, M.; Ochôa Matos, C.; Nicolau, R.; Bernardes, M.; Santos Faria, M.; Eugénio, G.; Barcelos, A. |
| Subject: | Biological therapies Immunoglobulin A Nephropathy Renal Spondylarthritis Spondyloarthropathies (including psoriatic arthritis) Rheumatology SDG 3 - Good Health and Well-being |
| Year: | 2025 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Universidade Nova de Lisboa |
| Language: | English |
| Origin: | Repositório Institucional da UNL |
| Summary: | Spondyloarthritis is a group of inflammatory rheumatic diseases characterized by inflammation of the spine and sacroiliac joints. Extra-musculoskeletal manifestations may also occur, although kidney involvement is rarely reported. Immunoglobulin A nephropathy is one of the most common types of glomerulonephritis, and it can be primary or associated with various diseases, such as spondyloarthritis. Several cases have been reported, mostly through case reports and small case series, pointing to a possible common pathophysiology between these two diseases. However, there is scarce information on the prevalence of renal involvement, particularly Immunoglobulin A nephropathy, among Spondyloarthritis Portuguese patients. We present 5 cases of Immunoglobulin A nephropathy in patients with Spondyloarthritis, resulting from a multicentre Portuguese collaboration, accompanied by a systematic literature review to understand this possible association. |
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