Publicação
FucoPol-based eutectogels For Biomedical Applications
| Resumo: | In recent years, sustainable soft materials have attracted considerable notoriety and attention. These materials are typically highly flexible, biocompatible, and tunable, making them suitable for applications in biomedicine, pharmaceuticals, and advanced materials. This thesis investigates the production of eutectogel membranes composed by the polymer FucoPol and phenolic-based eutectic solvents, aiming to combine the bioactive properties of phenolic compounds and FucoPol with the structural and mechanical prop- erties of this polymer, for potential wound dressing applications. FucoPol was synthesized by the bacterium Enterobacter A47, and the eutectic solvents were prepared by mixing choline chloride with the phenolic compounds 2-Phenylethanol, Pyrogallol, and Gallic Acid. FucoPol and eutectic solvents were combined to produce eutectogel membranes via dry casting method. These membranes demonstrated the controlled release of phenolic compounds at non-toxic concentrations, suggesting their potential for safe skin contact applications. Among the eutectic mixtures, ChCl:2-phenylethanol exhibited the lowest cytotoxicity and optimal diffusion rate. Additionally, this eutectic solvent exhibited significant antibacterial activity against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The membranes also displayed high thermal stability, with no signs of degradation or structural changes up to 150°C . These findings indicated that the prepared eutectogel membranes were stable, nontoxic, and exhibited promising antimicrobial properties, making them suitable for biomedical and pharmaceutical applications. Future research should focus on further characterizing the mechanical properties and exploring additional biological activities, such as anti-inflammatory and antioxidant effects, associated with phenolic compounds and FucoPol. |
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| Autores principais: | Inácio, Diogo Batista |
| Assunto: | FucoPol Eutectogel Eutectic Solvents Phenolic Compounds |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | In recent years, sustainable soft materials have attracted considerable notoriety and attention. These materials are typically highly flexible, biocompatible, and tunable, making them suitable for applications in biomedicine, pharmaceuticals, and advanced materials. This thesis investigates the production of eutectogel membranes composed by the polymer FucoPol and phenolic-based eutectic solvents, aiming to combine the bioactive properties of phenolic compounds and FucoPol with the structural and mechanical prop- erties of this polymer, for potential wound dressing applications. FucoPol was synthesized by the bacterium Enterobacter A47, and the eutectic solvents were prepared by mixing choline chloride with the phenolic compounds 2-Phenylethanol, Pyrogallol, and Gallic Acid. FucoPol and eutectic solvents were combined to produce eutectogel membranes via dry casting method. These membranes demonstrated the controlled release of phenolic compounds at non-toxic concentrations, suggesting their potential for safe skin contact applications. Among the eutectic mixtures, ChCl:2-phenylethanol exhibited the lowest cytotoxicity and optimal diffusion rate. Additionally, this eutectic solvent exhibited significant antibacterial activity against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The membranes also displayed high thermal stability, with no signs of degradation or structural changes up to 150°C . These findings indicated that the prepared eutectogel membranes were stable, nontoxic, and exhibited promising antimicrobial properties, making them suitable for biomedical and pharmaceutical applications. Future research should focus on further characterizing the mechanical properties and exploring additional biological activities, such as anti-inflammatory and antioxidant effects, associated with phenolic compounds and FucoPol. |
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