Publicação
THE IMPACT OF DEFECTIVE HOST CELL GLYCOSYLATION IN BACTERIAL INFECTION
| Resumo: | "Bacterial infections are a growing concern within medicine, in particular for vulnerable populations. This thesis delves with the crucial role of host glycans in host-pathogen interactions, that serve as beacon targets for tissue recognition and allow adhesion by pathogens, while functioning as sentinels, driving the host’s immune response. Congenital Disorders of Glycosylation are a group of rare diseases resulting from defects in cell glycosylation. PMM2-CDG, the most prevalent CDG, presents a deficit in N-glycosylation and is mainly known for its neurological involvement. Still, PMM2-CDG has almost 20% pediatric mortality associated with infection. Recent studies showed patients have higher propensity to respiratory, gastrointestinal, and severe infections in PMM2-CDG, but the affected immune mechanisms are still unknown.(...)" |
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| Autores principais: | Mexia, Patrícia Alexandra Nunes |
| Assunto: | Congenital Disorders of Glycosylation PMM2-CDG immune response bacterial infection and adhesion |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | "Bacterial infections are a growing concern within medicine, in particular for vulnerable populations. This thesis delves with the crucial role of host glycans in host-pathogen interactions, that serve as beacon targets for tissue recognition and allow adhesion by pathogens, while functioning as sentinels, driving the host’s immune response. Congenital Disorders of Glycosylation are a group of rare diseases resulting from defects in cell glycosylation. PMM2-CDG, the most prevalent CDG, presents a deficit in N-glycosylation and is mainly known for its neurological involvement. Still, PMM2-CDG has almost 20% pediatric mortality associated with infection. Recent studies showed patients have higher propensity to respiratory, gastrointestinal, and severe infections in PMM2-CDG, but the affected immune mechanisms are still unknown.(...)" |
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