Publicação
Light-responsive on-demand drug-delivery systems for dermal applications
| Resumo: | Chronic wounds are portrayed as an anomaly in the healing process. Economically speaking this type of wounds lead to a burden in the healthcare system due to the need of specialised clinicians and the overall cost of the treatment. Furthermore, the patient undergoes notable physical and emotional discomfort. The employment of Drug Delivery Systems (DDSs) in patch form can be advantageous in this condition as it can provide a boundary between the environment and the body, maintaining the correct moisture, and supplying the necessary drugs with a lower period- icity. The use of light as the stimuli to release the therapeutic agent brings an added value to the DDSs as it has a noninvasive nature, it’s efficiently applied and has a high spacial and temporal control. With the above information in mind, the present work consisted in the development, through the electrospinning and electrospray techniques, and characterization of Cellulose Acetate (CA)+Ibuprofen (Ibu)+Poly(3-hexylthiophene) (P3HT) membranes for controlled drug release. Regarding the drug release tests, with the use of Ultraviolet (UV) light a increase in the Ibu concentration was observed in all the membranes when compared with the respective passive release values. In the infrared light test, CA+Ibu+P3HT(spray) and CA+Ibu+P3HT(blend) membranes don’t reach their passive values, while the CA+Ibu and CA membrane reach and surpasse the passive value, respectively. This work presents good prospects for application in dermal treatment, but it is necessary to carry out additional studies, such as cytotoxicity analysis and optimization of the morphological and electrical properties of the membranes produced. |
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| Autores principais: | Mendes, Mariana Santos |
| Assunto: | Controlled drug release electrospinning cellulose acetate ibuprofen P3HT light stimuli |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | Chronic wounds are portrayed as an anomaly in the healing process. Economically speaking this type of wounds lead to a burden in the healthcare system due to the need of specialised clinicians and the overall cost of the treatment. Furthermore, the patient undergoes notable physical and emotional discomfort. The employment of Drug Delivery Systems (DDSs) in patch form can be advantageous in this condition as it can provide a boundary between the environment and the body, maintaining the correct moisture, and supplying the necessary drugs with a lower period- icity. The use of light as the stimuli to release the therapeutic agent brings an added value to the DDSs as it has a noninvasive nature, it’s efficiently applied and has a high spacial and temporal control. With the above information in mind, the present work consisted in the development, through the electrospinning and electrospray techniques, and characterization of Cellulose Acetate (CA)+Ibuprofen (Ibu)+Poly(3-hexylthiophene) (P3HT) membranes for controlled drug release. Regarding the drug release tests, with the use of Ultraviolet (UV) light a increase in the Ibu concentration was observed in all the membranes when compared with the respective passive release values. In the infrared light test, CA+Ibu+P3HT(spray) and CA+Ibu+P3HT(blend) membranes don’t reach their passive values, while the CA+Ibu and CA membrane reach and surpasse the passive value, respectively. This work presents good prospects for application in dermal treatment, but it is necessary to carry out additional studies, such as cytotoxicity analysis and optimization of the morphological and electrical properties of the membranes produced. |
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