Publicação
Sensory and motor representations in the inferior olive of larval zebrafish
| Resumo: | "The olivo-cerebellar system plays a pivotal role in sensorimotor con- trol and coordination in vertebrates. According to a classical theory of cerebellar cortex, the inferior olive (IO) provides Purkinje cells with error information which drives motor learning in the cerebellum. Even though this process has been extensively studied over the last five decades, it re- mains unclear whether the nature of IO signals is more sensory, motor or both. In this thesis we address the nature of sensory and motor rep- resentations in the IO of larval zebrafish and investigate their potential interactions and spatial organization. We presented a set of visual stimuli to larval zebrafish and recorded calcium activity in genetically identified IO neurons with a 2-photon microscope while simultaneously tracking the fishes’ eye and tail movements. We found that most IO responses were binocular, direction selective and spatially organized.(...)" |
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| Autores principais: | Félix, Rita |
| Assunto: | olivo-cerebellar system larval zebrafish |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | tese de doutoramento |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | "The olivo-cerebellar system plays a pivotal role in sensorimotor con- trol and coordination in vertebrates. According to a classical theory of cerebellar cortex, the inferior olive (IO) provides Purkinje cells with error information which drives motor learning in the cerebellum. Even though this process has been extensively studied over the last five decades, it re- mains unclear whether the nature of IO signals is more sensory, motor or both. In this thesis we address the nature of sensory and motor rep- resentations in the IO of larval zebrafish and investigate their potential interactions and spatial organization. We presented a set of visual stimuli to larval zebrafish and recorded calcium activity in genetically identified IO neurons with a 2-photon microscope while simultaneously tracking the fishes’ eye and tail movements. We found that most IO responses were binocular, direction selective and spatially organized.(...)" |
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