Publicação
Deciphering the roles of ribonuclease PNPase in the human pathogen Listeria monocytogenes:
| Resumo: | "PNPase is a 3’-5’ exoribonuclease that catalyses the degradation and processing of RNA. Although PNPase has been associated to virulence-related processes in bacteria, the regulatory networks under control of PNPase that contribute to virulence remain mostly elusive. Here, we studied the function of PNPase in the Gram-positive pathogenic bacterium Listeria monocytogenes, the infectious agent responsible for listeriosis, a foodborne infection associated with high morbidity and mortality in humans. L. monocytogenes is a facultative intracellular microorganism that thrives in a wide range of environmental conditions and endures different external stresses. Moreover, L. monocytogenes can adhere and form biofilms in several types of surfaces, namely in food-processing environments, making this bacterium a major burden for the food industry.(...)" |
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| Autores principais: | Quendera, Ana Patrícia |
| Assunto: | Bacteria ranscriptomic studies bacterial pathogenicity |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | tese de doutoramento |
| Tipo de acesso: | acesso embargado |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| Resumo: | "PNPase is a 3’-5’ exoribonuclease that catalyses the degradation and processing of RNA. Although PNPase has been associated to virulence-related processes in bacteria, the regulatory networks under control of PNPase that contribute to virulence remain mostly elusive. Here, we studied the function of PNPase in the Gram-positive pathogenic bacterium Listeria monocytogenes, the infectious agent responsible for listeriosis, a foodborne infection associated with high morbidity and mortality in humans. L. monocytogenes is a facultative intracellular microorganism that thrives in a wide range of environmental conditions and endures different external stresses. Moreover, L. monocytogenes can adhere and form biofilms in several types of surfaces, namely in food-processing environments, making this bacterium a major burden for the food industry.(...)" |
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