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Adding value to chicory roots: Evaluation of the anti-inflammatory potential of terpenes for application in Inflammatory Bowel Disease

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Detalhes bibliográficos
Resumo:"Inflammatoryboweldisease(IBD)isachronicgastrointestinalconditionaffecting nearly 5millionindividualsglobally,posingasubstantialpublichealthchallenge.IBD is amultifactorialdisorder,involvinganintricateinterplayamongtheimmunesystem, environmentalfactors,geneticsusceptibility,andalterationsingutmicrobiota.Upto date,thereisnocureforIBD,andcurrenttherapeuticstrategieshaveinherentlimi- tations.Apartfromtheirhighcosts,thesesymptomatictreatmentsexhibitsideeffects and oftenexperiencediminishedefficacyovertime,leadingtoarecurrentpatternofre- lapseandremission.GiventhemultifacetednatureofIBDanditsindividualvariability, thereisanurgentdemandforthediscoveryofinnovativeandeffectivepharmacological leads, toaddresstheshortcomingsassociatedwithexistingtherapies.(...)"
Autores principais:Matos, Melanie S.
Assunto:Inflammatory bowel disease chicory SLs cell-based model inflamed intestinal mucosa
Ano:2024
País:Portugal
Tipo de documento:tese de doutoramento
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL
Descrição
Resumo:"Inflammatoryboweldisease(IBD)isachronicgastrointestinalconditionaffecting nearly 5millionindividualsglobally,posingasubstantialpublichealthchallenge.IBD is amultifactorialdisorder,involvinganintricateinterplayamongtheimmunesystem, environmentalfactors,geneticsusceptibility,andalterationsingutmicrobiota.Upto date,thereisnocureforIBD,andcurrenttherapeuticstrategieshaveinherentlimi- tations.Apartfromtheirhighcosts,thesesymptomatictreatmentsexhibitsideeffects and oftenexperiencediminishedefficacyovertime,leadingtoarecurrentpatternofre- lapseandremission.GiventhemultifacetednatureofIBDanditsindividualvariability, thereisanurgentdemandforthediscoveryofinnovativeandeffectivepharmacological leads, toaddresstheshortcomingsassociatedwithexistingtherapies.(...)"