Publicação
Solitary Fibrous Tumor of the Breast: A Rare Case
| Resumo: | Abstract A solitary fibrous tumor (SFT) is a rare neoplasm often found in the pleura. Breast SFT is extremely rare, with just a few cases reported in the literature. The 49-year-old woman presented with a palpable lump in right breast. Mammography revealed an oval circumscribed mass which on ultrasound corresponded to a well-defined hypoechoic nodule. The imaging findings are not pathognomonic, therefore definitive diagnosis requires histological examination and immune-histochemical analysis. Histologically, neoplastic cells may adopt spindle to ovoid morphology, and the growth pattern is variable. In the immune-histochemical study, the tumor cells are characterized by strong and diffuse positivity for CD34 and STAT-6. In conclusion, breast SFT is rare. Histology may show overlapping characteristics with other conditions, with STAT-6 being a sensitive and specific marker that makes the definitive diagnosis. Surgical resection is the gold standard treatment. Although most have a benign and indolent clinical course, long-term follow-up is recommended. |
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| Autores principais: | Teixeira,Sofia |
| Outros Autores: | Flor-de-Lima,Beatriz; Cardoso,António; Madureira,António |
| Assunto: | Breast Solitary fibrous tumor Benign tumor. |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | relatório |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| Resumo: | Abstract A solitary fibrous tumor (SFT) is a rare neoplasm often found in the pleura. Breast SFT is extremely rare, with just a few cases reported in the literature. The 49-year-old woman presented with a palpable lump in right breast. Mammography revealed an oval circumscribed mass which on ultrasound corresponded to a well-defined hypoechoic nodule. The imaging findings are not pathognomonic, therefore definitive diagnosis requires histological examination and immune-histochemical analysis. Histologically, neoplastic cells may adopt spindle to ovoid morphology, and the growth pattern is variable. In the immune-histochemical study, the tumor cells are characterized by strong and diffuse positivity for CD34 and STAT-6. In conclusion, breast SFT is rare. Histology may show overlapping characteristics with other conditions, with STAT-6 being a sensitive and specific marker that makes the definitive diagnosis. Surgical resection is the gold standard treatment. Although most have a benign and indolent clinical course, long-term follow-up is recommended. |
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