Publicação

Proteína plasmática A associada à gravidez como marcador de restrição de crescimento fetal: o que se sabe até agora?

Detalhes bibliográficos
Resumo:	Fetal growth restriction (FGR) is a challenging complication of pregnancy characterized by severe perinatal morbidity and mortality and long-term adult disease. In this condition, the fetus does not reach his potential growth and is pathologically small. Several biomarkers have been studied as possible predictors of this condition. Pregnancy-associated plasma protein-A stands out as a potential marker of FGR. It is a trophoblast-derived protein involved in the insulin-like growth factor system regulation and thus in the fetal growth. The aim of this review is to assess the current evidence behind the association between this biochemical marker and FGR.
Autores principais:	Ornelas,Mariana
Outros Autores:	Ramalho,Carla
Assunto:	PAPP-A Fetal growth restriction Small for gestational age Growth potential Birthweight
Ano:	2018
País:	Portugal
Tipo de documento:	artigo
Tipo de acesso:	acesso aberto
Instituição associada:	Fundação para a Ciência e Tecnologia
Idioma:	português
Origem:	SciELO Portugal

Descrição
Resumo:	Fetal growth restriction (FGR) is a challenging complication of pregnancy characterized by severe perinatal morbidity and mortality and long-term adult disease. In this condition, the fetus does not reach his potential growth and is pathologically small. Several biomarkers have been studied as possible predictors of this condition. Pregnancy-associated plasma protein-A stands out as a potential marker of FGR. It is a trophoblast-derived protein involved in the insulin-like growth factor system regulation and thus in the fetal growth. The aim of this review is to assess the current evidence behind the association between this biochemical marker and FGR.