Publicação
Kaposi’s sarcoma: a 15-year retrospective study in a Portuguese hospital
| Resumo: | Abstract Objectives: To characterize the demographic and clinical aspects and describe the therapeutic approaches used in patients with Kaposi’s sarcoma at Hospital Garcia de Orta. Methods: A retrospective, descriptive, and observational study that included patients with a histological diagnosis of Kaposi’s sarcoma at Hospital Garcia de Orta between March 2009 and March 2024. Results: A total of 55 patients were included, 43 males and 12 females, with an average age at diagnosis of 63.55 years. The majority of patients (67.3%) had lesions in a single anatomical location, mainly in the lower limbs. The most frequently observed subtype was classic (38.2%), followed by epidemic (36.4%), endemic (23.6%) and, finally, iatrogenic (1.8%). The time from symptom onset to diagnosis was longer in the endemic subtype (40.78 months). The epidemic subtype had the highest proportion of patients with systemic involvement (55%). The majority of patients (56.4%) underwent monotherapy. There was heterogeneity in the therapeutic modalities used. Conclusion: This study highlights there is still a considerable delay in diagnosis, underlines the evolving demographic characteristics of the disease, and emphasizes the importance of adapting treatment to the subtype and extent of the disease. |
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| Autores principais: | Leme,Hugo J. |
| Outros Autores: | Ramos,José; Magarreiro-Silva,António; Gouveia,Ana I.; Alves,João |
| Assunto: | Kaposi’s sarcoma Classification HIV Human herpesvirus 8 |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| Resumo: | Abstract Objectives: To characterize the demographic and clinical aspects and describe the therapeutic approaches used in patients with Kaposi’s sarcoma at Hospital Garcia de Orta. Methods: A retrospective, descriptive, and observational study that included patients with a histological diagnosis of Kaposi’s sarcoma at Hospital Garcia de Orta between March 2009 and March 2024. Results: A total of 55 patients were included, 43 males and 12 females, with an average age at diagnosis of 63.55 years. The majority of patients (67.3%) had lesions in a single anatomical location, mainly in the lower limbs. The most frequently observed subtype was classic (38.2%), followed by epidemic (36.4%), endemic (23.6%) and, finally, iatrogenic (1.8%). The time from symptom onset to diagnosis was longer in the endemic subtype (40.78 months). The epidemic subtype had the highest proportion of patients with systemic involvement (55%). The majority of patients (56.4%) underwent monotherapy. There was heterogeneity in the therapeutic modalities used. Conclusion: This study highlights there is still a considerable delay in diagnosis, underlines the evolving demographic characteristics of the disease, and emphasizes the importance of adapting treatment to the subtype and extent of the disease. |
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