Publicação
RECALCITRANT HERPETIC GENITAL ULCERS TREATED WITH IMIQUIMOD IN ASSOCIATION WITH VALACYCLOVIR
| Resumo: | The herpes simplex virus is a common cause of genital ulcers. In the immunocompromised, it may have an atypical presentation, with exuberant lesions, frequently resulting in resistance to the mainstream therapeutic options, and a consequent prolonged course.A 25-year-old male with a previous history of common variable immunodeficiency, presented with herpetic extensive genital ulcerations on the inguinoscrotal region. Despite a long period of valacyclovir therapy, the patient remained symptomatic. We decided to add topical 5% imiquimod as an adjunctive therapy, and observed a completed resolution of the ulcerations.Imiquimod, working as a local immunomodulator, stimulates the anti-viral immunologic response. Therefore, it is an alternative in recalcitrant herpetic lesions, especially in the setting of immunosuppression. |
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| Autores principais: | Matos, Diogo |
| Outros Autores: | Alves, João; António, Ana Marta; Coelho, Ricardo; Bártolo, Elvira |
| Assunto: | Imiquimod Herpes genitalis Herpes simplex Ulcer Valaciclovir Imiquimod Ulcer Herpes genitais Herpes simples Valaciclovir |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Instituição associada: | Sociedade Portuguesa de Dermatologia e Venereologia |
| Idioma: | português |
| Origem: | Portuguese Journal of Dermatology |
| Resumo: | The herpes simplex virus is a common cause of genital ulcers. In the immunocompromised, it may have an atypical presentation, with exuberant lesions, frequently resulting in resistance to the mainstream therapeutic options, and a consequent prolonged course.A 25-year-old male with a previous history of common variable immunodeficiency, presented with herpetic extensive genital ulcerations on the inguinoscrotal region. Despite a long period of valacyclovir therapy, the patient remained symptomatic. We decided to add topical 5% imiquimod as an adjunctive therapy, and observed a completed resolution of the ulcerations.Imiquimod, working as a local immunomodulator, stimulates the anti-viral immunologic response. Therefore, it is an alternative in recalcitrant herpetic lesions, especially in the setting of immunosuppression. |
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