Publicação
Acute confusional state as the presenting feature of primary hyperparathyroidism
| Resumo: | Severe neuropsychological syndromes have beenpreviously described in association with primary hyperparathyroidism. The aetiopathogenic mechanisms underlying these rare neurological manifestations remain to be elucidated, as well as thebest therapeutic options, in such cases. We reportthe clinical case of a 68-year-old woman, who wasadmitted to the hospital because of an acuteconfusional state, in whom initial clinical investigation revealed severe hypercalcemia. Confusion persisted after correction of the calcium levels and a diagnosis of primary hyperparathyroidism wassubsequently established on detection of elevatedlevels of serum parathyroid hormone. The patientunderwent parathyroidectomy with a progressiveremission of the neuropsychiatric manifestations.This case illustrates an extremely rare presentingform of primary hyperparathyroidism, consisting inan acute confusional syndrome that persisted aftercorrection of hypercalcemia and that remitted onlyafter surgical treatment of the disease. A brief reviewof the mechanisms involved in the aetiopathogenesisof the neuropsychological manifestations of primaryhyperparathyroidism is presented. |
|---|---|
| Autores principais: | Ribeiro, João M. |
| Outros Autores: | Lucas, Margarida; Vitorino, Rui M. M. |
| Assunto: | hiperparatiroidismo primário síndroma confusional hipercalcemia manifestações psiquiátricas primary hyperparathyroidism confusional states hypercalcemia psychiatric manifestations |
| Ano: | 2000 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Instituição associada: | Sociedade Portuguesa de Medicina Interna |
| Idioma: | português |
| Origem: | Revista Portuguesa de Medicina Interna |
| Resumo: | Severe neuropsychological syndromes have beenpreviously described in association with primary hyperparathyroidism. The aetiopathogenic mechanisms underlying these rare neurological manifestations remain to be elucidated, as well as thebest therapeutic options, in such cases. We reportthe clinical case of a 68-year-old woman, who wasadmitted to the hospital because of an acuteconfusional state, in whom initial clinical investigation revealed severe hypercalcemia. Confusion persisted after correction of the calcium levels and a diagnosis of primary hyperparathyroidism wassubsequently established on detection of elevatedlevels of serum parathyroid hormone. The patientunderwent parathyroidectomy with a progressiveremission of the neuropsychiatric manifestations.This case illustrates an extremely rare presentingform of primary hyperparathyroidism, consisting inan acute confusional syndrome that persisted aftercorrection of hypercalcemia and that remitted onlyafter surgical treatment of the disease. A brief reviewof the mechanisms involved in the aetiopathogenesisof the neuropsychological manifestations of primaryhyperparathyroidism is presented. |
|---|