Publicação
Trends in Human Brucellosis: A 12-year Study of Admissions in a District Hospital
| Resumo: | Introduction: Human brucellosis can present various clinicalforms and potentially lead to an important social-economicburden. High level of clinical suspicion and appropriate laboratorytesting interpretation are essential for the diagnosis.The aim of this study was to review the admissions attributableto brucellosis in a public hospital of an endemic region of Portugal.Methods: Retrospective observational study of consecutivehospital admissions with a discharge diagnosis of brucellosisbetween 2000 and 2012, by the analysis of epidemiological,clinical, laboratory and therapeutic features.Results: A total of 36 patients were included. The percentageof male patients was 69.4%, with mean age of 52.9 years oldand 72.2% presented a risk factor exposure for brucellosis.We found 14 admissions in 2000 and zero admissions in 2012.The most reported frequent symptoms were fever (72%), myalgia(58.3%) and asthenia (47.2%). The rose bengal test waspositive for the majority of the tested patients (91.7%). On theother hand, only one patient had a positive culture for brucellosis.The disease was essentially acute (75%) and focalized(69%). When focalized, osteoarticular involvement wasthe most frequent presentation (37%). In univariate analysis,patients who relapsed (16.6%) showed no significant associationwith any of the epidemiologic, clinical, laboratory ortherapeutic features (p > 0.05). Antibiotic regimen most oftenprescribed was rifampicin plus doxycycline (55.5%).Conclusion: In our study, hospital admissions due to brucellosisdropped dramatically between 2000 and 2012, whichshows an optimistic sign of disease control. Acute and focalizedforms of the disease were the most frequent manifestationsof this zoonosis that is still a challenge for clinicians. |
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| Autores principais: | Baldo, Maria João |
| Outros Autores: | Vale, Fátima; Cardoso, Adriano; Pinho, Inês |
| Assunto: | Brucelose/diagnóstico Brucelose/epidemiologia Brucelose/tratamento Brucellosis/diagnosis Brucellosis/epidemiology Brucellosis/therapy |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | Sociedade Portuguesa de Medicina Interna |
| Idioma: | inglês |
| Origem: | Revista Portuguesa de Medicina Interna |
| Resumo: | Introduction: Human brucellosis can present various clinicalforms and potentially lead to an important social-economicburden. High level of clinical suspicion and appropriate laboratorytesting interpretation are essential for the diagnosis.The aim of this study was to review the admissions attributableto brucellosis in a public hospital of an endemic region of Portugal.Methods: Retrospective observational study of consecutivehospital admissions with a discharge diagnosis of brucellosisbetween 2000 and 2012, by the analysis of epidemiological,clinical, laboratory and therapeutic features.Results: A total of 36 patients were included. The percentageof male patients was 69.4%, with mean age of 52.9 years oldand 72.2% presented a risk factor exposure for brucellosis.We found 14 admissions in 2000 and zero admissions in 2012.The most reported frequent symptoms were fever (72%), myalgia(58.3%) and asthenia (47.2%). The rose bengal test waspositive for the majority of the tested patients (91.7%). On theother hand, only one patient had a positive culture for brucellosis.The disease was essentially acute (75%) and focalized(69%). When focalized, osteoarticular involvement wasthe most frequent presentation (37%). In univariate analysis,patients who relapsed (16.6%) showed no significant associationwith any of the epidemiologic, clinical, laboratory ortherapeutic features (p > 0.05). Antibiotic regimen most oftenprescribed was rifampicin plus doxycycline (55.5%).Conclusion: In our study, hospital admissions due to brucellosisdropped dramatically between 2000 and 2012, whichshows an optimistic sign of disease control. Acute and focalizedforms of the disease were the most frequent manifestationsof this zoonosis that is still a challenge for clinicians. |
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