Bibliographic Details
| Summary: | Schizophrenia is a common psychiatric disorder with a complex genetic etiology. To understand the genetic basis of this syndrome in Portuguese Island populations, we performed a genome-wide scan of 29 families with schizophrenia, which identified a single region on 5q31-5q35 with strong linkage (NPL=3.09, P=0.0012 at D5S820). Empirical simulations set a genome-wide threshold of NPL=3.10 for significant linkage. Additional support for this locus in schizophrenia comes from higher-density mapping and mapping of 11 additional families. The combined set of 40 families had a peak NPL=3.28 (P=0.00066) at markers D5S2112-D5S820. These data and previous linkage findings from other investigators provide strong and consistent evidence for this genomic region as a susceptibility locus for schizophrenia. Exploratory analyses of a novel phenotype, psychosis, in families with schizophrenia and bipolar disorder detected evidence for linkage to the same markers as found in schizophrenia (peak NPL=3.03, P=0.0012 at D5S820), suggesting that this locus may be responsible for the psychotic symptoms observed in both diseases. |
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| Main Authors: | Sklar, P. |
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| Other Authors: | Pato, Michele T.; Kirby, A. N.; Petryshen, T. L.; Medeiros, Helena; Carvalho, Célia; Macedo, António; Dourado, A.; Coelho, I.; Valente, J.; Soares, M. J.; Ferreira, Carlos Paz; Lei, M.; Verner, A.; Hudson, T. J.; Morley, C. P.; Kennedy, J. L.; Azevedo, Maria H.; Lander, E.; Daly, M. J.; Pato, Carlos N. |
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| Subject: | Schizophrenia Psychiatric Disorder Genetic |
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| Year: | 2004 |
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| Country: | Portugal |
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| Document type: | article |
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| Access type: | restricted access |
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| Associated institution: | Universidade dos Açores |
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| Language: | English |
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| Origin: | Repositório da Universidade dos Açores |
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