Publicação
Canine copper-associated hepatitis : a retrospective study of 17 clinical cases
| Resumo: | Copper-associated hepatitis is a well-recognized chronic hepatic disease in dogs. While in some animals the condition is due to a genetic defect on copper metabolism, in others it is still unclear whether its accumulation is a primary or a secondary condition. Nowadays, reports of non-genetically predisposed dogs are increasing. This retrospective study aims to describe epidemiologic factors and clinical findings of dogs with copper-associated hepatitis. All dogs presented to a French veterinary referral center from May 2010 to March 2017, with positive rhodanine staining on liver biopsies were included. Medical records were retrospectively analyzed for: age of presentation, gender, breed, main clinical complaints, abdominal ultrasound findings and rhodanine staining pattern. A total of 17 dogs were included. Similarly to previous studies, German Shepherd and Terriers were overrepresented. Less common breeds were also reported namely Beauceron and American Staffordshire which, despite being a Terrier, has not been previously associated with copper-associated hepatitis. Incidental finding of increased liver-enzymes activity emphasizes the silent progression of the disease. Although ultrasound abnormalities were inconsistent, the heterogenous mottled liver was a common finding. The centrilobular pattern of rhodanine staining observed in the majority of cases strengthens the primary condition of the disease. In 3 dogs a periportal distribution was observed and copper-deposition was believed to be secondary to cholestasis. To the author’s knowledge, this is the first study describing copper-associated hepatitis in Beauceron and American Staffordshire terrier dogs. This study increases the number of reported breeds affected by copper-associated hepatitis, emphasizing a possible multifactorial etiology. |
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| Autores principais: | Rodrigues, Anthony de Sousa |
| Assunto: | Copper-associated hepatitis clinical signs diagnostic biopsy rhodanine Hepatite associada ao cobre sinais clínicos diagnóstico biópsia rodanina Hépatite par surcharge en cuivre signes cliniques biopsie |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Copper-associated hepatitis is a well-recognized chronic hepatic disease in dogs. While in some animals the condition is due to a genetic defect on copper metabolism, in others it is still unclear whether its accumulation is a primary or a secondary condition. Nowadays, reports of non-genetically predisposed dogs are increasing. This retrospective study aims to describe epidemiologic factors and clinical findings of dogs with copper-associated hepatitis. All dogs presented to a French veterinary referral center from May 2010 to March 2017, with positive rhodanine staining on liver biopsies were included. Medical records were retrospectively analyzed for: age of presentation, gender, breed, main clinical complaints, abdominal ultrasound findings and rhodanine staining pattern. A total of 17 dogs were included. Similarly to previous studies, German Shepherd and Terriers were overrepresented. Less common breeds were also reported namely Beauceron and American Staffordshire which, despite being a Terrier, has not been previously associated with copper-associated hepatitis. Incidental finding of increased liver-enzymes activity emphasizes the silent progression of the disease. Although ultrasound abnormalities were inconsistent, the heterogenous mottled liver was a common finding. The centrilobular pattern of rhodanine staining observed in the majority of cases strengthens the primary condition of the disease. In 3 dogs a periportal distribution was observed and copper-deposition was believed to be secondary to cholestasis. To the author’s knowledge, this is the first study describing copper-associated hepatitis in Beauceron and American Staffordshire terrier dogs. This study increases the number of reported breeds affected by copper-associated hepatitis, emphasizing a possible multifactorial etiology. |
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