Publicação
Microbial translocation and immune activation in HIV infection
| Resumo: | Human Immunodeficiency Virus (HIV)-1 associated immunodeficiency is characterized by a loss of CD4 T-cells. This loss has been linked to a state of chronic immune activation, which by itself is thought to influence the prognosis of HIV-1 infected individuals. In this review, we analyse the contribute of microbial translocation to this state of persistent immune activation. Microbial translocation is a consequence of gut mucosal damage associated with HIV-1, and its recovery upon sustained antiretroviral therapy (ART) is still controversial. We also provide a brief comparative analysis of the different markers of microbial translocation, as its association with persistent immune activation. Finally, we will discuss the development of complementary therapeutics to ART that aim to improve intestinal mucosa homeostasis, to control the inflammatory process and lastly the prognosis of HIV-1 infected patients. |
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| Autores principais: | Nogueira, Augusto Luís |
| Assunto: | HIV Infecções por HIV Translocação microbiana |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Human Immunodeficiency Virus (HIV)-1 associated immunodeficiency is characterized by a loss of CD4 T-cells. This loss has been linked to a state of chronic immune activation, which by itself is thought to influence the prognosis of HIV-1 infected individuals. In this review, we analyse the contribute of microbial translocation to this state of persistent immune activation. Microbial translocation is a consequence of gut mucosal damage associated with HIV-1, and its recovery upon sustained antiretroviral therapy (ART) is still controversial. We also provide a brief comparative analysis of the different markers of microbial translocation, as its association with persistent immune activation. Finally, we will discuss the development of complementary therapeutics to ART that aim to improve intestinal mucosa homeostasis, to control the inflammatory process and lastly the prognosis of HIV-1 infected patients. |
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