Detalhes bibliográficos
| Resumo: | Alpha-synuclein (aSyn) misfolding and aggregation are pathological features common to several neurodegenerative diseases, including Parkinson's disease (PD). Mounting evidence suggests that aSyn can be secreted and transferred from cell to cell, participating in the propagation and spreading of pathological events. Rab11, a small GTPase, is an important regulator in both endocytic and secretory pathways. Here, we show that Rab11 is involved in regulating aSyn secretion. Rab11 knockdown or overexpression of either Rab11a wild-type (Rab11a WT) or Rab11a GDP-bound mutant (Rab11a S25N) increased secretion of aSyn. Furthermore, we demonstrate that Rab11 interacts with aSyn and is present in intracellular inclusions together with aSyn. Moreover, Rab11 reduces aSyn aggregation and toxicity. Our results suggest that Rab11 is involved in modulating the processes of aSyn secretion and aggregation, both of which are important mechanisms in the progression of aSyn pathology in PD and other synucleinopathies. |
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| Autores principais: | Chutna, Oldriska |
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| Outros Autores: | Goncalves, Susana; Villar-Pique, Anna; Guerreiro, Patrícia; Marijanovic, Zrinka; Mendes, Tiago; Ramalho, José; Emmanouilidou, Evangelia; Ventura, Salvador; Klucken, Jochen; Barral, Duarte C.; Giorgini, Flaviano; Vekrellis, Kostas; Outeiro, Tiago |
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| Assunto: | Bodily secretions Guanosine triphosphate phosphohydrolases Transfection toxic effect |
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| Ano: | 2014 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade de Lisboa |
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| Idioma: | inglês |
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| Origem: | Repositório da Universidade de Lisboa |
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