Publicação
Colangiocarcinoma intrahepático de células claras
| Resumo: | Clear cell intrahepatic cholangiocarcinoma is a rare variant of intrahepatic cholangiocarcinoma with only ten reported cases in the literature. This tumor needs to be differentiated from clear cell variant of hepatocellular carcinoma and other metastatic clear cell carcinomas. Hence, it is important to correctly diagnose this entity and differentiate it from other histologic mimics. We describe clinical, histopathological, and immunohistochemical findings of one such rare case in a 51-year-old woman with diabetes type II and systemic hipertension who was detected to have an intrahepatic tumor at routine ultrasound examination. After extensive workup for other primary neoplasms the patient underwent partial hepatectomy. On immunohistochemical staining, cytokeratin (CK) 7, CK8, CK18 and CK19 were positive, whereas CK20 was negative. The patient is currently free from disease at 12-months follow-up. A review of all the similar cases reported so far in the literature is also provided. |
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| Autores principais: | Rodrigues, Mónica Teixeira |
| Assunto: | Colangiocarcinoma Gastroenterologia |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Clear cell intrahepatic cholangiocarcinoma is a rare variant of intrahepatic cholangiocarcinoma with only ten reported cases in the literature. This tumor needs to be differentiated from clear cell variant of hepatocellular carcinoma and other metastatic clear cell carcinomas. Hence, it is important to correctly diagnose this entity and differentiate it from other histologic mimics. We describe clinical, histopathological, and immunohistochemical findings of one such rare case in a 51-year-old woman with diabetes type II and systemic hipertension who was detected to have an intrahepatic tumor at routine ultrasound examination. After extensive workup for other primary neoplasms the patient underwent partial hepatectomy. On immunohistochemical staining, cytokeratin (CK) 7, CK8, CK18 and CK19 were positive, whereas CK20 was negative. The patient is currently free from disease at 12-months follow-up. A review of all the similar cases reported so far in the literature is also provided. |
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