Publicação
Integrating sleep-related breathing disorders and epigenetics into the genetic landscape of sleep disturbances in psychotic disorders
| Resumo: | Recent advances in psychiatric genetics have underscored the role of polygenic scores (PGSs) in shaping sleep phenotypes in individuals with psychotic disorders. The study by Cederlöf et al. (Reference Cederlöf, Holm, Kämpe, Ahola-Olli, Kantojärvi, Lähteenvuo and Paunio2025) makes an important contribution by leveraging genome-wide association data to disentangle the complex interplay between genetic liability for insomnia, sleep duration, chronotype, and schizophrenia. Their findings offer compelling insights into how distinct genetic risks manifest in both subjective experiences and cognitive performance. Yet, the genetic landscape of sleep in psychosis is even more nuanced than the current framework suggests. Several biologically and clinically relevant dimensions—namely sleep-related breathing disorders (SRBDs), the COMISA phenotype (comorbid insomnia and sleep apnea), and the dynamic influence of epigenetic regulation—warrant deeper integration into this conversation. |
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| Autores principais: | Perdigoto, Susana |
| Outros Autores: | De Pedro, Miguel; Meira e Cruz, Miguel |
| Assunto: | COMISA Comorbid insomnia and sleep apnea Epigenetics Genetics Insomnia Obstructive sleep apnea Psychiatric Psychosocial health Psychotic disorders Sleep apnea Sleep disturbances Sleep-disordered breathing |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Recent advances in psychiatric genetics have underscored the role of polygenic scores (PGSs) in shaping sleep phenotypes in individuals with psychotic disorders. The study by Cederlöf et al. (Reference Cederlöf, Holm, Kämpe, Ahola-Olli, Kantojärvi, Lähteenvuo and Paunio2025) makes an important contribution by leveraging genome-wide association data to disentangle the complex interplay between genetic liability for insomnia, sleep duration, chronotype, and schizophrenia. Their findings offer compelling insights into how distinct genetic risks manifest in both subjective experiences and cognitive performance. Yet, the genetic landscape of sleep in psychosis is even more nuanced than the current framework suggests. Several biologically and clinically relevant dimensions—namely sleep-related breathing disorders (SRBDs), the COMISA phenotype (comorbid insomnia and sleep apnea), and the dynamic influence of epigenetic regulation—warrant deeper integration into this conversation. |
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