Publicação
VPAC2 receptor activation mediates VIP enhancement of population spikes in the CA1 area of the hippocampus
| Resumo: | The receptors mediating vasoactive intestinal polypeptide (VIP) enhancement of synaptic transmission to pyramidal cell bodies were investigated. RO 25–1553 (VPAC2 agonist) mimicked the excitatory effect of VIP on population spike (PS) amplitude. [K15, R16, L27]VIP (1–7)/GRF (8–27) (VPAC1 agonist) caused only a small increase in PS amplitude. The effect ofVPAC2 agonist (but not of theVPAC1 agonist)persisted upon blockade of GABAergic transmission and was strongly attenuated upon inhibition of PKA. In conclusion, VPAC2 receptor activation mediates VIP enhancement of PS amplitude in the hippocampus essentially through a PKA-dependent mechanism. |
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| Autores principais: | Cunha-Reis, Diana |
| Outros Autores: | Ribeiro, Joaquim A.; Sebastião, Ana M |
| Assunto: | VIP VPAC1 VPAC2 PKA PKC Hippocampus |
| Ano: | 2006 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | The receptors mediating vasoactive intestinal polypeptide (VIP) enhancement of synaptic transmission to pyramidal cell bodies were investigated. RO 25–1553 (VPAC2 agonist) mimicked the excitatory effect of VIP on population spike (PS) amplitude. [K15, R16, L27]VIP (1–7)/GRF (8–27) (VPAC1 agonist) caused only a small increase in PS amplitude. The effect ofVPAC2 agonist (but not of theVPAC1 agonist)persisted upon blockade of GABAergic transmission and was strongly attenuated upon inhibition of PKA. In conclusion, VPAC2 receptor activation mediates VIP enhancement of PS amplitude in the hippocampus essentially through a PKA-dependent mechanism. |
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