Detalhes bibliográficos
| Resumo: | This study tested the hypothesis that naturally and industrially produced trans-fatty acids can exert distinct efects on metabolic parameters and on gut microbiota of rats. Wistar rats were randomized into three groups according to the diet: CONT-control, with 5% soybean oil and normal amount of fat; HVF-20% of hydrogenated vegetable fat (industrial); and RUM-20% of ruminant fat (natural). After 53 days of treatment, serum biochemical markers, fatty acid composition of liver, heart and adipose tissue, histology and hepatic oxidative parameters, as well as gut microbiota composition were evaluated. HVF diet intake reduced triglycerides (≈ 39.39%) and VLDL levels (≈ 39.49%). Transfatty acids levels in all tissue were higher in HVF group. However, RUM diet intake elevated amounts of anti-infammatory cytokine IL-10 (≈ 14.7%) compared to CONT, but not to HVF. Furthermore, RUM intake led to higher concentrations of stearic acid and conjugated linoleic acid in all tissue; this particular diet was associated with a hepatoprotective efect. The microbial gut communities were signifcantly diferent among the groups. Our results show that ruminant fat reversed the hepatic steatosis normally caused by high fat diets, which may be related to the remodelling of the gut microbiota and its anti-infammatory potential. |
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| Autores principais: | Medeiros, Larissa de Brito |
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| Outros Autores: | Alves, Susana Paula; Bessa, R.J.B.; Soares, Juliana Késsia Barbosa; Costa, Camila Neves Meireles; Aquino, Jailane de Souza; Guerra, Gerlane Coelho Bernardo; Araújo, Daline Fernandes de Souza; Toscano, LydianeTavares; Silva, Alexandre Sérgio; Alves, Adriano Francisco; Lemos, Mateus Lacerda Pereira; Araujo, Wydemberg José de; Medeiros, Ariosvaldo Nunes de; Oliveira, Celso José Bruno de; Queiroga, Rita de Cassia Ramos do Egypto |
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| Assunto: | Diets Consunption Nutrition Health Trans-11 Obesity Food Cholesterol Metabolism Modulation |
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| Ano: | 2021 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade de Lisboa |
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| Idioma: | inglês |
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| Origem: | Repositório da Universidade de Lisboa |
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