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A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid

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Detalhes bibliográficos
Resumo:Background/Aims: Ursodeoxycholic acid (UDCA) and its taurine-conjugated derivative, TUDCA, modulate cell death and cell cycle regulators, such as E2F-1 and p53. However, precise pathways underlying UDCA's effects are not fully understood. The aim of this
Autores principais:Castro, RE
Outros Autores:Sola, S; Ma, XM; Ramalho, RM; Kren, BT; Steer, CJ; Rodrigues, CMP
Assunto:Gastroenterology & Hepatology
Ano:2005
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso a metadados
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa
Descrição
Resumo:Background/Aims: Ursodeoxycholic acid (UDCA) and its taurine-conjugated derivative, TUDCA, modulate cell death and cell cycle regulators, such as E2F-1 and p53. However, precise pathways underlying UDCA's effects are not fully understood. The aim of this