Publicação
Carcinoma e leucemia da glândula lacrimal: a raridade num caso clinico
| Resumo: | Introduction: Although beeing rare, the tumors of the lacrimal gland are associated with high morbility and mortality. There is also the possibility of involvement of this structure by systemic pathologies like leukemia. Nontheless this is rarely reported. Case Report: A 64-year-old woman presented with proptosis of the right eye since 1992 with a growth in the beginning of 2010. The CT revealed an unsuspicious extra-conical orbital lesion. The biopsy showed a nonspecific inflammatory infiltrate. In a latter CT in 2012 this lesion was found to be compatible with a neoplastic process, so it was excised and the histopathology exposed a carcinoma expleomorphic adenoma with infiltration of the borders with cells from chronic lymphocytic leukemia.Laboratory tests revealed leukocytosis with lymphocytosis with an immunophenotype compatible with chronic lymphocytic leukemia of B cells. The patient remained without proptosis or limitation of motility, with regular clinical monitoring. Discussion: The present case is distinguished by simultaneously presenting two rare orbital pathologies and there are no reports of similar cases. This coexistence leads us to question the possible existence of common pathophysiological mechanisms between these two neoplastic lesions. |
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| Autores principais: | Mira, Catarina de Oliveira |
| Assunto: | Neoplasia Glândula lacrimal Oftalmologia |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Introduction: Although beeing rare, the tumors of the lacrimal gland are associated with high morbility and mortality. There is also the possibility of involvement of this structure by systemic pathologies like leukemia. Nontheless this is rarely reported. Case Report: A 64-year-old woman presented with proptosis of the right eye since 1992 with a growth in the beginning of 2010. The CT revealed an unsuspicious extra-conical orbital lesion. The biopsy showed a nonspecific inflammatory infiltrate. In a latter CT in 2012 this lesion was found to be compatible with a neoplastic process, so it was excised and the histopathology exposed a carcinoma expleomorphic adenoma with infiltration of the borders with cells from chronic lymphocytic leukemia.Laboratory tests revealed leukocytosis with lymphocytosis with an immunophenotype compatible with chronic lymphocytic leukemia of B cells. The patient remained without proptosis or limitation of motility, with regular clinical monitoring. Discussion: The present case is distinguished by simultaneously presenting two rare orbital pathologies and there are no reports of similar cases. This coexistence leads us to question the possible existence of common pathophysiological mechanisms between these two neoplastic lesions. |
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