Detalhes bibliográficos
| Resumo: | Dipeptide esters of paracetamol were prepared in high yields. These compounds are quantitatively hydrolyzed to paracetamol and corresponding 2,5-diketopiperazines at pH 7.4 and 37 ° C. The reactivity is increased in sarcosine and proline peptides and decreased by bulky side chains at both the N- and C-terminal residues of the dipeptide carrier. Moreover, dipeptide esters of paracetamol did not affect the levels of hepatic glutathione. Thus, dipeptides seem promising candidates as carriers for cyclization-activated prodrugs. © 2005 Elsevier Ltd. All rights reserved. |
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| Autores principais: | Santos, C |
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| Outros Autores: | Mateus, ML; dos Santos, AP; Moreira, R; de Oliveira, E; Gomes, P |
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| Assunto: | Chemistry, Medicinal Chemistry, Organic |
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| Ano: | 2005 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso a metadados |
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| Instituição associada: | Universidade de Lisboa |
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| Idioma: | inglês |
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| Origem: | Repositório da Universidade de Lisboa |
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