Publicação
Métodos de produção de pós para inalação oral
| Resumo: | The administration of drugs to the lung by inhalation is a very attractive approach, primarily due to the characteristics of the target organ, the lung. Besides the use of pulmonary delivery for the treatment of local diseases such as asthma, the huge surface area of the lungs, the thin epithelium and the large and constant blood supply mean that it's also an interesting way to deliver drugs meant for systemic absorption. One way to get the drugs to the lungs is by way of dry powder inhalation. However, due to the morphology of the airways, particles meant for inhalation need to have some characteristics to make it possible. Most important is their size, but other factors such as shape also affect the aerodynamic behavior of powder particles. This work explores the methods and technologies that can be used to produce powders for oral inhalation, the characteristics of the particles they produce and possible new approaches for the future. It concludes that the most used are pulverization, particularly jet-milling, and spray-drying but that other technologies, such as freeze-spray-drying and crystallization can also be used. More recently, these technologies have been used in novel ways and for the administration of biopharmaceuticals. |
|---|---|
| Autores principais: | Penetra, João Pedro Rasquinho |
| Assunto: | Mestrado Integrado - 2014 Dry powder inhalers Freeze-spray- drying Milling Particle size Pulmonary route Spray-drying |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | The administration of drugs to the lung by inhalation is a very attractive approach, primarily due to the characteristics of the target organ, the lung. Besides the use of pulmonary delivery for the treatment of local diseases such as asthma, the huge surface area of the lungs, the thin epithelium and the large and constant blood supply mean that it's also an interesting way to deliver drugs meant for systemic absorption. One way to get the drugs to the lungs is by way of dry powder inhalation. However, due to the morphology of the airways, particles meant for inhalation need to have some characteristics to make it possible. Most important is their size, but other factors such as shape also affect the aerodynamic behavior of powder particles. This work explores the methods and technologies that can be used to produce powders for oral inhalation, the characteristics of the particles they produce and possible new approaches for the future. It concludes that the most used are pulverization, particularly jet-milling, and spray-drying but that other technologies, such as freeze-spray-drying and crystallization can also be used. More recently, these technologies have been used in novel ways and for the administration of biopharmaceuticals. |
|---|