Publicação
L-Mesitran® in the management of canine otitis externa
| Resumo: | At a time when antimicrobial resistance is rising steadily and the involved microorganisms are demonstrating zoonotic potential, honey and its derived products may prove useful in this ongoing battle. Otitis externa in dogs is considered to be one of the most prominent causes for presentation at veterinary practice. Some of the regularly administered agents in otitis treatments are no longer effective, as resistance has increased, perhaps due to the often long-term periods which are necessary for resolution and the accompanying tendency towards chronicity. In order to address the need for efficient alternative treatments, LMesitran ® Soft, a medical grade honey gel was used to treat 15 dogs with otitis externa of bacterial and/or fungal involvement. Success was based on clinical score decrease, cytology and owner input over time and with basis on culture results. 70% of enrolled dogs achieved clinical cure between days 7 to 14 and over 90% on day 21, the maximum established time limit, with a confidence interval of 95%. Furthermore, by day 7, 20% of dogs had obtained both clinical and cytological cures. This study was successfully able to demonstrate that the use of L-Mesitran® was effective in managing otitis externa in dogs, including cases in which highly resistant pathogens were present, such as methicillinresistant Staphylococcus pseudintermedius (MRSP), thus paving the way to future studies. |
|---|---|
| Autores principais: | Maruhashi, Emi |
| Assunto: | Honey Antimicrobial resistance Canine Otitis externa L-Mesitran® Soft Methicillin-resistant Staphylococcus pseudintermedius (MRSP) Mel Resistência antimicrobiana Canina Otite externa Staphylococcus pseudintermedius resistente à meticilina (SPRM) |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | At a time when antimicrobial resistance is rising steadily and the involved microorganisms are demonstrating zoonotic potential, honey and its derived products may prove useful in this ongoing battle. Otitis externa in dogs is considered to be one of the most prominent causes for presentation at veterinary practice. Some of the regularly administered agents in otitis treatments are no longer effective, as resistance has increased, perhaps due to the often long-term periods which are necessary for resolution and the accompanying tendency towards chronicity. In order to address the need for efficient alternative treatments, LMesitran ® Soft, a medical grade honey gel was used to treat 15 dogs with otitis externa of bacterial and/or fungal involvement. Success was based on clinical score decrease, cytology and owner input over time and with basis on culture results. 70% of enrolled dogs achieved clinical cure between days 7 to 14 and over 90% on day 21, the maximum established time limit, with a confidence interval of 95%. Furthermore, by day 7, 20% of dogs had obtained both clinical and cytological cures. This study was successfully able to demonstrate that the use of L-Mesitran® was effective in managing otitis externa in dogs, including cases in which highly resistant pathogens were present, such as methicillinresistant Staphylococcus pseudintermedius (MRSP), thus paving the way to future studies. |
|---|