Publicação
An innovative strategy for cell-based therapeutic neovascularization: the use of angiogenic microniches in an experimental model of hindlimb ischemia
| Resumo: | Critical limb ischemia (CLI), the end stage of peripheral arterial disease (PAD), is diagnosed in patients that present chronic ischemic pain at rest and skin lesions, including ulcers and gangrene. Surgical revascularization is the goldstandard treatment but 30% of CLI patients require amputation in the first year, a procedure associated with high morbidity and mortality. Therapeutic angiogenesis, through transplantation of proangiogenic stem cells, became a promising approach for the clinical management of ischemic vascular diseases. However, several clinical trials demonstrated less consistent positive results due to the mode of cell administration that results in high rates of cell death, poor retention, survival and functional loss. So, it is imperative to improve cell delivery strategies. In this work, it is our objective to investigate the potential of an integrative cell therapy (CT) approach for therapeutic vascularization. |
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| Autores principais: | Costa, Catarina Ferreira da |
| Assunto: | Terapia celular Células Estaminais Mesenquimais Células Endoteliais Microgéis Esferóides Teses de mestrado - 2019 |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Critical limb ischemia (CLI), the end stage of peripheral arterial disease (PAD), is diagnosed in patients that present chronic ischemic pain at rest and skin lesions, including ulcers and gangrene. Surgical revascularization is the goldstandard treatment but 30% of CLI patients require amputation in the first year, a procedure associated with high morbidity and mortality. Therapeutic angiogenesis, through transplantation of proangiogenic stem cells, became a promising approach for the clinical management of ischemic vascular diseases. However, several clinical trials demonstrated less consistent positive results due to the mode of cell administration that results in high rates of cell death, poor retention, survival and functional loss. So, it is imperative to improve cell delivery strategies. In this work, it is our objective to investigate the potential of an integrative cell therapy (CT) approach for therapeutic vascularization. |
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