Publicação
A função respiratória dos doentes adultos com fibrose quística, em repouso e no esforço
| Resumo: | Cystic fibrosis is a genetic disease which affects many systems, being lung impairment the leading cause of death in these individuals. The main purpose of this project is to evaluate the respiratory function of these patients as well as its determinant factors. Data from 37 adults with CF was collected, and their respiratory function assessed, at rest, through respiratory function tests (LFTs); and during exercise through the six minute walk test (6MWT). Different statistical methods were applied to identify associations between potential determinants of aggravated respiratory function and subsequent clinical deterioration. Several variables that correlated with %FEV1 or %FEV1 decline, as gender, BMI, pancreatic function, CFRD, number of admissions per year and infection by Pseudomonas and fungi were identified. Ascertained correlations between distance and fungal infection, basal and final PaO2, number of admissions and final heart rate. The desaturation also correlated with the number of admissions, %VR, %FEF25 -75 and %FEV1. Clinical deterioration can be measured by several parameters, which is essential to recognize those that change prematurely, since most of the pathophysiological changes associated with the natural history of the disease, can be prevented or are potentially treatable. The application of serial LFTs and 6MWT enables a more assertive medical conduct, particularly in adjusting therapeutic measures. |
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| Autores principais: | Costa, Ana Rita |
| Assunto: | Fibrose quística Função respiratória |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Cystic fibrosis is a genetic disease which affects many systems, being lung impairment the leading cause of death in these individuals. The main purpose of this project is to evaluate the respiratory function of these patients as well as its determinant factors. Data from 37 adults with CF was collected, and their respiratory function assessed, at rest, through respiratory function tests (LFTs); and during exercise through the six minute walk test (6MWT). Different statistical methods were applied to identify associations between potential determinants of aggravated respiratory function and subsequent clinical deterioration. Several variables that correlated with %FEV1 or %FEV1 decline, as gender, BMI, pancreatic function, CFRD, number of admissions per year and infection by Pseudomonas and fungi were identified. Ascertained correlations between distance and fungal infection, basal and final PaO2, number of admissions and final heart rate. The desaturation also correlated with the number of admissions, %VR, %FEF25 -75 and %FEV1. Clinical deterioration can be measured by several parameters, which is essential to recognize those that change prematurely, since most of the pathophysiological changes associated with the natural history of the disease, can be prevented or are potentially treatable. The application of serial LFTs and 6MWT enables a more assertive medical conduct, particularly in adjusting therapeutic measures. |
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