Publicação
Incorporation of superparamagnetic nanoparticle clusters in liposomes by thin film method
| Resumo: | Nanoparticle research is, at the moment, one of the most studied branches of science and is emerging as one of the fastest growing areas which includes different fields such as biology, medicine, optics, electronics or pharmaceutical technology, among others. In the last few years, it has emerged as a strategy, in pharmaceutical technology, to overcome problems related with drug delivery. Magnetoliposomes, consisting in liposomes surrounding and iron oxide core, surge as a very promising drug delivery system, which is not only capable of targeting a drug but also follow its efficiency, through diagnose methods, such as MRI, allowing to make a prognosis of the treatment - Theranostic. The purpose of this work was to synthesize, characterize and study the incorporation of superparamagnetic nanoparticle clusters into liposomes by thin film method. Starting by studying the lipidic variation of the components of the membrane, along with an analysis of the effect of reducing the amount of magnetic particles to incorporate, and finally the selection of the stereo stabilizer which provides a better long-term stability. These were some of the steps taken to get to this paper and to find a stable formulation that, although it seems appropriated to function as theranostic agent, still needs more research. |
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| Autores principais: | Martins, Joana Isabel Calado |
| Assunto: | Mestrado Integrado - 2014 |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Nanoparticle research is, at the moment, one of the most studied branches of science and is emerging as one of the fastest growing areas which includes different fields such as biology, medicine, optics, electronics or pharmaceutical technology, among others. In the last few years, it has emerged as a strategy, in pharmaceutical technology, to overcome problems related with drug delivery. Magnetoliposomes, consisting in liposomes surrounding and iron oxide core, surge as a very promising drug delivery system, which is not only capable of targeting a drug but also follow its efficiency, through diagnose methods, such as MRI, allowing to make a prognosis of the treatment - Theranostic. The purpose of this work was to synthesize, characterize and study the incorporation of superparamagnetic nanoparticle clusters into liposomes by thin film method. Starting by studying the lipidic variation of the components of the membrane, along with an analysis of the effect of reducing the amount of magnetic particles to incorporate, and finally the selection of the stereo stabilizer which provides a better long-term stability. These were some of the steps taken to get to this paper and to find a stable formulation that, although it seems appropriated to function as theranostic agent, still needs more research. |
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