Publicação
Isopimarane diterpenoids from Aeollanthus rydingianus and their antimicrobial activity
| Resumo: | Four acyloxy-isopimarane derivatives along with two known isopimarane diterpenoids, the flavone cirsimaritin and the sterols P-sitosterol and stigmasterol were isolated from the aerial parts of Aeollanthus rydingianus. The structures of the compounds were established on the basis of spectroscopic analysis and chemical evidence. The isolated substances were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and a yeast strain. 19-Acetoxy-7,15-isopimaradien-3 beta-ol and 7,15-isopimaradien-19-ol showed minimum inhibitory concentration (MIC) values of 3.90-15.62 mu g/ml for Staphylococcus aureus and of 7.81 mu g/ml for Enterococcus hirae. (C) 2009 Elsevier Ltd. All rights reserved.. - Portuguese "Fundacao para a Ciencia e a Tecnologia" [SFRH/BD/19250/2004]; Spanish "Comision Interministerial de Ciencia y Tecnologia" [CTQ2006-15279-C03-02]. - We are grateful to Ernst van Jaarsveld, horticulturist, Kirstenbosch National Botanic Gardens (South Africa), for providing cuttings of A. rydingianus, and to Teresa Vasconcelos, researcher LIS[ (Lisbon), for the growing of the plants. This work was supported by funds from the Portuguese "Fundacao para a Ciencia e a Tecnologia" (FCT-MCES, to iMed.UL and as PhD Grant No. SFRH/BD/19250/2004) and also from the Spanish "Comision Interministerial de Ciencia y Tecnologia" (CICYT, Grant No. CTQ2006-15279-C03-02). |
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| Autores principais: | Rijo, Patricia |
| Outros Autores: | Simoes, Maria Fatima; Duarte, Aida; Rodriguez, Benjamin |
| Assunto: | Biochemistry & Molecular Biology Plant Sciences |
| Ano: | 2009 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso a metadados |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Four acyloxy-isopimarane derivatives along with two known isopimarane diterpenoids, the flavone cirsimaritin and the sterols P-sitosterol and stigmasterol were isolated from the aerial parts of Aeollanthus rydingianus. The structures of the compounds were established on the basis of spectroscopic analysis and chemical evidence. The isolated substances were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and a yeast strain. 19-Acetoxy-7,15-isopimaradien-3 beta-ol and 7,15-isopimaradien-19-ol showed minimum inhibitory concentration (MIC) values of 3.90-15.62 mu g/ml for Staphylococcus aureus and of 7.81 mu g/ml for Enterococcus hirae. (C) 2009 Elsevier Ltd. All rights reserved.. - Portuguese "Fundacao para a Ciencia e a Tecnologia" [SFRH/BD/19250/2004]; Spanish "Comision Interministerial de Ciencia y Tecnologia" [CTQ2006-15279-C03-02]. - We are grateful to Ernst van Jaarsveld, horticulturist, Kirstenbosch National Botanic Gardens (South Africa), for providing cuttings of A. rydingianus, and to Teresa Vasconcelos, researcher LIS[ (Lisbon), for the growing of the plants. This work was supported by funds from the Portuguese "Fundacao para a Ciencia e a Tecnologia" (FCT-MCES, to iMed.UL and as PhD Grant No. SFRH/BD/19250/2004) and also from the Spanish "Comision Interministerial de Ciencia y Tecnologia" (CICYT, Grant No. CTQ2006-15279-C03-02). |
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