Publicação
Development of antibody-directed therapies: quo vadis?
| Resumo: | Less is more: The efficacy of antibody-drug conjugates (ADCs) for cancer therapy is traditionally associated with cleavable linkers for payload release. Evidence now suggests that simpler constructs without cleavable moieties can afford more stable and effective ADCs. |
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| Autores principais: | Rodrigues, Tiago |
| Outros Autores: | Bernardes, Gonçalo J. L. |
| Assunto: | Anti-tumor agents Antibody-drug conjugates Bioconjugation Drug delivery Linkers |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Less is more: The efficacy of antibody-drug conjugates (ADCs) for cancer therapy is traditionally associated with cleavable linkers for payload release. Evidence now suggests that simpler constructs without cleavable moieties can afford more stable and effective ADCs. |
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