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Structural and spectral assignment of three forskolin-like diterpenoids isolated from Plectranthus ornatus

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Summary:Three labdane diterpenoids were isolated from an acetone extract of Plectranthus ornatus. Their structures, closely related to that of forskolin, were determined by NMR studies. Unambiguous and complete assignments of the H-1 and C-13 NMR chemical shifts for these substances are presented. The assignments are based on 2D shift-correlated [H-1,H-1-COSY,H-1,C-13-gHSQC-(1)J (C,H), H-1, C-13-gHMBC-(n)J (C,H) (n = 2 and 3)] and NOE experiments. Copyright (c) 2005 John Wiley & Sons, Ltd.
Main Authors:Rijo, P
Other Authors:Simoes, MF; Rodriguez, B
Subject:Chemistry, Multidisciplinary Chemistry, Physical Spectroscopy
Year:2005
Country:Portugal
Document type:article
Access type:metadata only access
Associated institution:Universidade de Lisboa
Language:English
Origin:Repositório da Universidade de Lisboa
Description
Summary:Three labdane diterpenoids were isolated from an acetone extract of Plectranthus ornatus. Their structures, closely related to that of forskolin, were determined by NMR studies. Unambiguous and complete assignments of the H-1 and C-13 NMR chemical shifts for these substances are presented. The assignments are based on 2D shift-correlated [H-1,H-1-COSY,H-1,C-13-gHSQC-(1)J (C,H), H-1, C-13-gHMBC-(n)J (C,H) (n = 2 and 3)] and NOE experiments. Copyright (c) 2005 John Wiley & Sons, Ltd.