Publicação
Relationship between physical fitness, physical activity, and sedentary patterns with tumor and cardiometabolic biomarkers in women newly diagnosed with breast cancer
| Resumo: | Purpose: To analyze the relationship between physical fitness, physical activity (PA), and sedentary patterns with cardiometabolic and tumor biomarkers. Methods: 26 breast cancer (BC) patients were cross-sectionally assessed for PA levels, and sedentary time/patterns, cardiorespiratory fitness (CRF), and muscle strength (handgrip and mid-thigh pull (MTP) test). Further, body composition was evaluated by dual energy x-ray absorptiometry (DEXA). Waist circumference (WC) was obtained. Cardiometabolic biomarkers were assessed by blood analysis, and KI-67 by biopsy. Multiple linear regressions were used for data analysis. Results: CRF was negatively associated with C-Reactive Protein (CRP) (β: -0.52), WC (β: -0.51), fat mass percentage (%FM) (β: -0.78), and body mass index (BMI) (β: -0.50), even adjusting for sedentary time. A negative association was found between handgrip and triglycerides (β: -0.55, adjusting for age/type of biological cancer; β: -0.56, adjusting also for lean soft tissue), WC (β: -0.33), and %FM (β: -0.44), while adjusting for those three variables. Moderate-to-vigorous PA (MVPA) was negatively associated with %FM (β: -0.43), WC (β: -0.66), BMI (β: -0.52), and CRP (β: -0.54) while adjusting for age, type of biological cancer, and wear time. Breaks of sedentary time were positively correlated with CRP (β: 0.49) and BMI (β: 0.50) after adjusting for MVPA, while sedentary time was negatively associated with CRP (β: -0.71), WC (β: -0.74) and BMI (β: -0.68). Conclusion: Our results suggests that physical fitness and MVPA had favorable correlations with some cardiometabolic, tumor and body composition parameters in newly diagnosed BC patients. |
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| Autores principais: | Costa, Inês Ferreira |
| Assunto: | Sedentary Behavior Physical Activity Cardiorespiratory Fitness Muscle Strength KI-67 Metabolic Profile Inflammatory Profile Comportamento Sedentário Atividade Física Aptidão Cardiorrespiratória Força Muscular Perfil Metabólico Perfil Inflamatório |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Purpose: To analyze the relationship between physical fitness, physical activity (PA), and sedentary patterns with cardiometabolic and tumor biomarkers. Methods: 26 breast cancer (BC) patients were cross-sectionally assessed for PA levels, and sedentary time/patterns, cardiorespiratory fitness (CRF), and muscle strength (handgrip and mid-thigh pull (MTP) test). Further, body composition was evaluated by dual energy x-ray absorptiometry (DEXA). Waist circumference (WC) was obtained. Cardiometabolic biomarkers were assessed by blood analysis, and KI-67 by biopsy. Multiple linear regressions were used for data analysis. Results: CRF was negatively associated with C-Reactive Protein (CRP) (β: -0.52), WC (β: -0.51), fat mass percentage (%FM) (β: -0.78), and body mass index (BMI) (β: -0.50), even adjusting for sedentary time. A negative association was found between handgrip and triglycerides (β: -0.55, adjusting for age/type of biological cancer; β: -0.56, adjusting also for lean soft tissue), WC (β: -0.33), and %FM (β: -0.44), while adjusting for those three variables. Moderate-to-vigorous PA (MVPA) was negatively associated with %FM (β: -0.43), WC (β: -0.66), BMI (β: -0.52), and CRP (β: -0.54) while adjusting for age, type of biological cancer, and wear time. Breaks of sedentary time were positively correlated with CRP (β: 0.49) and BMI (β: 0.50) after adjusting for MVPA, while sedentary time was negatively associated with CRP (β: -0.71), WC (β: -0.74) and BMI (β: -0.68). Conclusion: Our results suggests that physical fitness and MVPA had favorable correlations with some cardiometabolic, tumor and body composition parameters in newly diagnosed BC patients. |
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