Publicação
Encefalopatia tardia da entoxicação por monóxido de carbono : case report e revisão de literatura
| Resumo: | Acute carbon monoxide intoxication is a common finding in the modern world. Less frequent is the observation of a late complication also known as Delayed Encephalopathy after Acute Carbon Monoxide Poisoning. A clinical triad consisting in mental status impairment, sphincters incontinence and gait disturbance is typical to find, with or without extrapyramidal signs, after a variable lucid period free of symptoms. The underlying pathogenic mechanism it’s not yet fully understood and results in large demyelination of the cerebral white matter, also described as leucoencephalopathy. After the onset of symptoms the diagnosis is easily made by Magnetic Resonance, however the difficulty in identifying patients who will develop this syndrome and the lack of consensus regarding the right medical approach not only in the acute phase but also after the first symptoms of delayed encephalopathy make this entity a challenge for any clinician. |
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| Autores principais: | Soares, Raquel de Almeida |
| Assunto: | Intoxicação aguda Encefalopatia tardia Monóxido de carbono |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Acute carbon monoxide intoxication is a common finding in the modern world. Less frequent is the observation of a late complication also known as Delayed Encephalopathy after Acute Carbon Monoxide Poisoning. A clinical triad consisting in mental status impairment, sphincters incontinence and gait disturbance is typical to find, with or without extrapyramidal signs, after a variable lucid period free of symptoms. The underlying pathogenic mechanism it’s not yet fully understood and results in large demyelination of the cerebral white matter, also described as leucoencephalopathy. After the onset of symptoms the diagnosis is easily made by Magnetic Resonance, however the difficulty in identifying patients who will develop this syndrome and the lack of consensus regarding the right medical approach not only in the acute phase but also after the first symptoms of delayed encephalopathy make this entity a challenge for any clinician. |
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