Publicação
Glandular gastric ulcers in horses : current knowlegde and its treatment
| Resumo: | ABSTRACT - The study of the differences in the pathogenesis and risk factors of equine gastric glandular and squamous diseases allows veterinarians to develop the most appropriate therapeutic and preventive strategies for their treatment. The aim of this work was to investigate and analyse the risk factors and response to treatment in Equine Glandular Gastric Disease (EGGD), for which there have been few studies. In this retrospective study, horses with various clinical signs and hospitalised at the Equine Unit of the Faculty of Veterinary Medicine of the University of Liège were diagnosed with EGGD and Equine Squamous Gastric Disease (ESGD) by gastroscopic examination. The sample group consisted of 53 horses of which only 18 had solely EGGD, while the others had mixed squamous and glandular gastric ulceration. The treatment duration corresponded to the "time between gastroscopies”, which ranged from three to six weeks, after which the horses were re-examined to assess the evolution of the gastric lesions. Of the 53 horses sampled, 11 were treated with misoprostol at a dosage of 5 μg/kg, per os BID, while the remainder were treated with omeprazole paste formulation at a dosage of 4mg/kg, per os, SID combined with sucralfate at a dosage of 12 mg/kg per os BID. Treatment was chosen according to the clinician's preference and on lesion location. Glandular gastric lesions were more common in mares over 10 years of age, and warmblood horses appear to be more susceptible to EGGD. There was no significant association between gender or age and treatment response in this study (P = 0,96) and (P = 0,62). A treatment period of four to fiveweeks using misoprostol appeared to be most effective in promoting healing or improvement of the lesions, compared with four weeks of treatment period with omeprazole-sucralfate. Neither breed nor time between gastroscopies significantly influenced the response of horses to treatment (P = 0,92) and (P = 0,14). Concomitant squamous ulcers did not appear to a significant effect on ulcer healing or improvement (P = 0,14). Glandular ulcers were more common in the pylorus (77,4%), followed by the pyloric antrum (13,2%), and the location of the lesion appeared to influence the response to treatment (P = 0,02). In terms of lesion distribution, multifocal lesions were the most common, but this did not appear to have an impact on response to therapy (P = 0,08). Although omeprazole sucralfate was prescribed more frequently by clinicians in the equine hospital, misoprostol proved superior to omeprazole-sucralfate in the treatment of EGGD in this study (P = 0,049) |
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| Autores principais: | Claro, Constança Reais Ferreira Calado |
| Assunto: | Medicina veterinária Equine Gastric Glandular Disease Omeprazole Misoprostol Prevention Gastroscopy Doença gástrica glandular equina Omeprazol Misoprostol Prevenção Gastroscopia |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | ABSTRACT - The study of the differences in the pathogenesis and risk factors of equine gastric glandular and squamous diseases allows veterinarians to develop the most appropriate therapeutic and preventive strategies for their treatment. The aim of this work was to investigate and analyse the risk factors and response to treatment in Equine Glandular Gastric Disease (EGGD), for which there have been few studies. In this retrospective study, horses with various clinical signs and hospitalised at the Equine Unit of the Faculty of Veterinary Medicine of the University of Liège were diagnosed with EGGD and Equine Squamous Gastric Disease (ESGD) by gastroscopic examination. The sample group consisted of 53 horses of which only 18 had solely EGGD, while the others had mixed squamous and glandular gastric ulceration. The treatment duration corresponded to the "time between gastroscopies”, which ranged from three to six weeks, after which the horses were re-examined to assess the evolution of the gastric lesions. Of the 53 horses sampled, 11 were treated with misoprostol at a dosage of 5 μg/kg, per os BID, while the remainder were treated with omeprazole paste formulation at a dosage of 4mg/kg, per os, SID combined with sucralfate at a dosage of 12 mg/kg per os BID. Treatment was chosen according to the clinician's preference and on lesion location. Glandular gastric lesions were more common in mares over 10 years of age, and warmblood horses appear to be more susceptible to EGGD. There was no significant association between gender or age and treatment response in this study (P = 0,96) and (P = 0,62). A treatment period of four to fiveweeks using misoprostol appeared to be most effective in promoting healing or improvement of the lesions, compared with four weeks of treatment period with omeprazole-sucralfate. Neither breed nor time between gastroscopies significantly influenced the response of horses to treatment (P = 0,92) and (P = 0,14). Concomitant squamous ulcers did not appear to a significant effect on ulcer healing or improvement (P = 0,14). Glandular ulcers were more common in the pylorus (77,4%), followed by the pyloric antrum (13,2%), and the location of the lesion appeared to influence the response to treatment (P = 0,02). In terms of lesion distribution, multifocal lesions were the most common, but this did not appear to have an impact on response to therapy (P = 0,08). Although omeprazole sucralfate was prescribed more frequently by clinicians in the equine hospital, misoprostol proved superior to omeprazole-sucralfate in the treatment of EGGD in this study (P = 0,049) |
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