Publicação
Dos biomarcadores ao estadiamento da perturbação bipolar : uma revisão bibliográfica
| Resumo: | A growing body of evidence suggests that Bipolar Disorder exhibits a progressive character, not only at clinical, but also at biochemical and neuroimaging perspectives. Morphometric studies in bipolar patients have shown the presence of neuroanatomical changes, such as ventricular enlargement, grey matter loss in the hippocampus and cerebellum, decrease in the volume of certain areas of the prefrontal cortex and variations in the size of the amygdala. Furthermore, other studies have reported changes in the levels of neurotrophic factors, inflammatory mediators and oxidative stress, in the plasma of bipolar disorder patients. The knowledge of the neurobiological and neuroimagiological changes, associated to the progression and activity of Bipolar Disorder is essential for biomarkers identification. Incorporating the use of biomarkers in Bipolar Disorder staging models may allow an improvement of the therapeutic algorithms, enabling the development of more personalized and effective treatment regimens. |
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| Autores principais: | Roda, Ângela Sofia Neto |
| Assunto: | Transtorno bipolar Biomarcadores |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | A growing body of evidence suggests that Bipolar Disorder exhibits a progressive character, not only at clinical, but also at biochemical and neuroimaging perspectives. Morphometric studies in bipolar patients have shown the presence of neuroanatomical changes, such as ventricular enlargement, grey matter loss in the hippocampus and cerebellum, decrease in the volume of certain areas of the prefrontal cortex and variations in the size of the amygdala. Furthermore, other studies have reported changes in the levels of neurotrophic factors, inflammatory mediators and oxidative stress, in the plasma of bipolar disorder patients. The knowledge of the neurobiological and neuroimagiological changes, associated to the progression and activity of Bipolar Disorder is essential for biomarkers identification. Incorporating the use of biomarkers in Bipolar Disorder staging models may allow an improvement of the therapeutic algorithms, enabling the development of more personalized and effective treatment regimens. |
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