Publicação
O sistema da tiorredoxina e o sistema imunitário
| Resumo: | The main function of the immune system is to protect the organism against agressors. This defense is achieved through biological processes like inflammation. During the inflammatory process it is produced several inflammatory mediators like citokines, chemokines and ROS. The production of ROS during the inflammatory process leads to oxidative stress which is one of the mechanisms of elimination of agressors. After elimination of aggressor, ROS are eliminated by antioxidant systems. Being thioredoxin system the main endogenous antioxidant system. Balance between antioxidant systems and oxidative species dictates de oxidative state of the cell. This oxidative state has an important effect in the regulation of enzymes and transcription factors that are oxidation-sensitive. This way, the regulation of many cellular activities is achieved through it’s oxidative state. Chronic inflammatory diseases result from the perpetuation of the inflammatory process. Among those are the neuroinflammatory diseases, where microglia cells are responsible for the presence of inflammation. Meanwhile, very little is known about the role of microglia cells in the development of neurodegenerative diseases. Phenotypic alterations in microglia cells can have different effects in the course of neurodegenerative diseases. The regulatory effect of thioredoxin system over some signal transduction pathways can come to be used in the regulation of microglia cells. This way, there should be studies on the effect of thioredoxin system in the regulation of microglia cells. |
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| Autores principais: | Horta, Manuel Maria Mexia de Almeida |
| Assunto: | Microglia Thioredoxin Redox Regulation Inflammation Mestrado Integrado - 2016 |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | The main function of the immune system is to protect the organism against agressors. This defense is achieved through biological processes like inflammation. During the inflammatory process it is produced several inflammatory mediators like citokines, chemokines and ROS. The production of ROS during the inflammatory process leads to oxidative stress which is one of the mechanisms of elimination of agressors. After elimination of aggressor, ROS are eliminated by antioxidant systems. Being thioredoxin system the main endogenous antioxidant system. Balance between antioxidant systems and oxidative species dictates de oxidative state of the cell. This oxidative state has an important effect in the regulation of enzymes and transcription factors that are oxidation-sensitive. This way, the regulation of many cellular activities is achieved through it’s oxidative state. Chronic inflammatory diseases result from the perpetuation of the inflammatory process. Among those are the neuroinflammatory diseases, where microglia cells are responsible for the presence of inflammation. Meanwhile, very little is known about the role of microglia cells in the development of neurodegenerative diseases. Phenotypic alterations in microglia cells can have different effects in the course of neurodegenerative diseases. The regulatory effect of thioredoxin system over some signal transduction pathways can come to be used in the regulation of microglia cells. This way, there should be studies on the effect of thioredoxin system in the regulation of microglia cells. |
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