Publicação
Multiple point stimulation MUNE in ALS: toward a faster modification
| Resumo: | Purpose: Multiple point stimulation is a well-established motor unit number estimate method that can be used in all EMG machines, but it is time-consuming. We investigated whether a faster modification of multiple point stimulation using five surface motor unit action potentials (sMUAP) had similar reproducibility, sensitivity, and specificity as 10. Methods: Twenty-two motor neuron disease patients and 20 healthy controls were prospectively examined by two physicians twice in the thenar muscles. Results: A total of 168 multiple point stimulation motor unit number estimate recordings were obtained. Mean motor unit number estimate was significantly lower in patients in contrast to the controls, whether using 5 (53 ± 55 [1-170] vs. 150 ± 64 (51-325), P < 0.001] or 10 sMUAP [52 ± 51 (1-162) vs. 151 ± 50 (75-274), P < 0.001]. No significant differences (P > 0.05) were found between mean motor unit number estimate obtained from 5 or 10 sMUAP in both patients and controls. Intra-rater coefficient of variation (CV) for patients (17% vs. 15%) and controls (16% vs. 13%) and inter-rater coefficient of variation for patients (25% vs. 24%) did not differ between five and 10 sMUAP (P > 0.05), whereas interrater coefficient of variation was higher for five sMUAP in controls (21% vs. 16%, P = 0.004). An excellent intraclass correlation coefficient (≥0.78) was found, sampling either 5 or 10 sMUAP, for both groups. Receiver operating characteristic curves collecting 5 or 10 sMUAP showed excellent accuracy in distinguishing between patients and controls. Conclusions: The faster modification of Multiple point stimulation by sampling five sMUAP had similar reproducibility, sensitivity, and specificity as 10 and may be suggested in future research and clinical practice. |
|---|---|
| Autores principais: | Oliveira Santos, Miguel |
| Outros Autores: | Jacobsen, Anna Bystrup; Tankisi, Hatice |
| Assunto: | Multiple point stimulation Motor unit number estimate Surface motor unit action potential Amyotrophic lateral sclerosis Reproducibility |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Purpose: Multiple point stimulation is a well-established motor unit number estimate method that can be used in all EMG machines, but it is time-consuming. We investigated whether a faster modification of multiple point stimulation using five surface motor unit action potentials (sMUAP) had similar reproducibility, sensitivity, and specificity as 10. Methods: Twenty-two motor neuron disease patients and 20 healthy controls were prospectively examined by two physicians twice in the thenar muscles. Results: A total of 168 multiple point stimulation motor unit number estimate recordings were obtained. Mean motor unit number estimate was significantly lower in patients in contrast to the controls, whether using 5 (53 ± 55 [1-170] vs. 150 ± 64 (51-325), P < 0.001] or 10 sMUAP [52 ± 51 (1-162) vs. 151 ± 50 (75-274), P < 0.001]. No significant differences (P > 0.05) were found between mean motor unit number estimate obtained from 5 or 10 sMUAP in both patients and controls. Intra-rater coefficient of variation (CV) for patients (17% vs. 15%) and controls (16% vs. 13%) and inter-rater coefficient of variation for patients (25% vs. 24%) did not differ between five and 10 sMUAP (P > 0.05), whereas interrater coefficient of variation was higher for five sMUAP in controls (21% vs. 16%, P = 0.004). An excellent intraclass correlation coefficient (≥0.78) was found, sampling either 5 or 10 sMUAP, for both groups. Receiver operating characteristic curves collecting 5 or 10 sMUAP showed excellent accuracy in distinguishing between patients and controls. Conclusions: The faster modification of Multiple point stimulation by sampling five sMUAP had similar reproducibility, sensitivity, and specificity as 10 and may be suggested in future research and clinical practice. |
|---|