Publicação
Anemia na doença inflamatória intestinal
| Resumo: | The Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that comprises predominantly two entities, Crohn's disease (CD) and Ulcerative Colitis (UC). IBD is more common in the second decade of life, particularly during adolescence. However, its prevalence at pediatric age has been increasing over the past decades, especially CD. To the set of gastrointestinal signs and symptoms that characterize these diseases, sum up a large number of significant systemic manifestations limiting of quality of life, including anemia. In the context of IBD, anemia is a common manifestation, often regarded as inevitable and therefore a source of concerns. This is a complex clinical condition with multifactorial etiology.There are no studies to corroborate the clinical importance of anemia in children with IBD and to determine the extent to which the correction is associated with improvements in disease activity. However, studies in adults showed an improved quality of life with the correction of the values of hemoglobin concentration, irrespective of disease activity. So this inference is adopted as true in the context of children and adolescents. Anemia is defined, depending on the etiology, into different types, being the most common ones the iron deficiency anemia (IDA) and the anemia of inflammatory cause or anemia of chronic disease (ACD), for which are adopted different therapeutic approaches.The therapeutic approach encompasses the treatment of the underlying disease, IBD, and this is the main therapeutic measure for ACD, but also iron administration through different formulations of iron with distinct characteristics and safety profiles, for IDA. |
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| Autores principais: | Barbosa, Benvinda Alexandra Martins Costa |
| Assunto: | Doença inflamatória intestinal Anemia Pediatria |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | The Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that comprises predominantly two entities, Crohn's disease (CD) and Ulcerative Colitis (UC). IBD is more common in the second decade of life, particularly during adolescence. However, its prevalence at pediatric age has been increasing over the past decades, especially CD. To the set of gastrointestinal signs and symptoms that characterize these diseases, sum up a large number of significant systemic manifestations limiting of quality of life, including anemia. In the context of IBD, anemia is a common manifestation, often regarded as inevitable and therefore a source of concerns. This is a complex clinical condition with multifactorial etiology.There are no studies to corroborate the clinical importance of anemia in children with IBD and to determine the extent to which the correction is associated with improvements in disease activity. However, studies in adults showed an improved quality of life with the correction of the values of hemoglobin concentration, irrespective of disease activity. So this inference is adopted as true in the context of children and adolescents. Anemia is defined, depending on the etiology, into different types, being the most common ones the iron deficiency anemia (IDA) and the anemia of inflammatory cause or anemia of chronic disease (ACD), for which are adopted different therapeutic approaches.The therapeutic approach encompasses the treatment of the underlying disease, IBD, and this is the main therapeutic measure for ACD, but also iron administration through different formulations of iron with distinct characteristics and safety profiles, for IDA. |
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