Publicação
Risk assessment conceptual model of occurrence of mycobacterium avium subspecies paratuberculosis in unprocessed beef and bovine milk
| Resumo: | Crohn’s Disease aetiology is currently unknown and Mycobacterium avium subspecies paratuberculosis (MAP) has been proposed as its etiologic agent. Despite the absence of a causal relationship between MAP and Crohn’s Disease, MAP has been frequently isolated in humans. Milk and beef consumption is considered a possible MAP source. Thus the risk of MAP occurrence on these products should be assessed. The main objective of this work was to assess the probability of MAP occurrence in unprocessed beef and bovine milk. In order to assemble the available data, an exhaustive literature search was made on the dissemination of MAP infection and MAP isolation by bacteriologic tissue culture. The main knowledge gaps found were the lack of detailed information on: i) MAP dissemination mechanism and the importance of faecal contamination; ii) relation between MAP dissemination and other indicators (clinical signs, gross lesions, immune response); iii) MAP prevalence on beef and milk by stage of infection. Due to the lack of this information, the risk assessment and the characterization of the risk mitigation measures could not be performed. The risk model pathways, its assumptions, data required and knowledge gaps are described in this work. Further research is needed to make available the mentioned knowledge gaps and to develop and to improve diagnostic tests for direct MAP detection on beef and bovine milk. |
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| Autores principais: | Marques, Diogo Filipe Pereira |
| Assunto: | Mycobacterium avium subspecies paratuberculosis Disseminated MAP infection Milk Beef Bovine Risk model pathway Risk assessment Infecção disseminada do MAP Leite Carne Bovinos |
| Ano: | 2009 |
| País: | Portugal |
| Tipo de documento: | trabalho de fim de curso |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Crohn’s Disease aetiology is currently unknown and Mycobacterium avium subspecies paratuberculosis (MAP) has been proposed as its etiologic agent. Despite the absence of a causal relationship between MAP and Crohn’s Disease, MAP has been frequently isolated in humans. Milk and beef consumption is considered a possible MAP source. Thus the risk of MAP occurrence on these products should be assessed. The main objective of this work was to assess the probability of MAP occurrence in unprocessed beef and bovine milk. In order to assemble the available data, an exhaustive literature search was made on the dissemination of MAP infection and MAP isolation by bacteriologic tissue culture. The main knowledge gaps found were the lack of detailed information on: i) MAP dissemination mechanism and the importance of faecal contamination; ii) relation between MAP dissemination and other indicators (clinical signs, gross lesions, immune response); iii) MAP prevalence on beef and milk by stage of infection. Due to the lack of this information, the risk assessment and the characterization of the risk mitigation measures could not be performed. The risk model pathways, its assumptions, data required and knowledge gaps are described in this work. Further research is needed to make available the mentioned knowledge gaps and to develop and to improve diagnostic tests for direct MAP detection on beef and bovine milk. |
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